ClinicalTrials.gg
CompletedNCT04379154VOC-COVIDUpdated Jan 27, 2022

Analysis of Volatile Organic Compounds by Electronic Noses in Hospitalised Patients for an Infection by SARS-COV-2 (COVID-19)

An interventional study of Volatile Organic Compounds analysis in COVID-19, sponsored by Hopital Foch. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-01-27.

Sponsored by Hopital Foch · Not applicable, Interventional, and Other

Phase
Not applicable
Study type
Interventional
Enrollment
65
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

The study of volatile organic compounds (VOCs) detected in exhaled air is an innovative research area for respiratory diseases. This analysis can be done by the technique of electronic nose, simpler and faster, which provides an idea of the general profile of the VOCs without identifying them. The VOCs in exhaled air in patients hospitalized for COVID-19 infection are analysed in this study, using electronic noses.

02

Conditions studied

  • COVID-19

Browse trials for

03

In context

COVID-19

7,774 studies on the registry are indexed under COVID-19; 482 are open to participants now.

This study's enrollment of 65 is below the median of 100 across 4,175 interventional studies indexed under COVID-19.

Browse COVID-19 studies →

Lead sponsor

Hopital Foch is the lead sponsor of 215 studies on the registry; 21 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients infected by SARS-CoV-2 whose medical condition warrants hospitalisation (out of intensive care) for oxygen therapy less or equal to 4 l/min
  • Patients must be 18 years of age or older
  • Fluent in the French language
  • Have signed a consent form
  • Being affiliated with healthcare insurance

Exclusion criteria

Exclusion Criteria:

  • Pregnant woman
  • Patient deprived of liberty by judicial or administrative decision
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
65 participants (actual)

Study arms

  • Experimental
    Volatile Organic Compounds analysis

    Volatile Organic Compounds analysis in exhaled air in patients hospitalised for COVID-19 infection

    Device: Volatile Organic Compounds analysis

Interventions

  • DeviceVolatile Organic Compounds analysis

    Volatile Organic Compounds analysis in exhaled air by electronic noses

06

What researchers measure

Primary outcomes

  1. Profiles of volatile organic compounds (VOCs) in exhaled air between 2 health conditions

    Comparison of variation of profiles of Volatile Organic Compounds in exhaled air from electronic noses (a set of sensors interacting with the VOCs exhaled). The analysis of the generated signal (resistance or load variations) is characteristic of the composition of VOCs), between patients who improve and patients who get worse during their hospitalisation for COVID-19 infection

    Time frame: 1 day

Secondary outcomes

  1. Profiles of volatile organic compounds (VOCs) in exhaled air on 1 health condition

    Comparison of variation of profiles of Volatile Organic Compounds in exhaled air from electronic noses (a set of sensors interacting with the VOCs exhaled. The analysis of the generated signal (resistance or load variations) is characteristic of the composition of VOCs), between the start and the discharge to the hospital in patients infecting and recovering from COVID-19.

    Time frame: 2 weeks

  2. Profiles of volatile organic compounds (VOCs) in exhaled air between 2 periods

    Comparison of variation of profiles of Volatile Organic Compounds in exhaled air from electronic noses (a set of sensors interacting with the VOCs exhaled. The analysis of the generated signal (resistance or load variations) is characteristic of the composition of VOCs), between the hospitalisation period and a post-hospitalisation follow-up consultation in patients infected by COVID-19 and recovered.

    Time frame: 4 months

  3. Profiles of volatile organic compounds (VOCs) in exhaled air by mass spectrometry at each visit based on patient evolution status.

    Comparison of variation of profiles of Volatile Organic Compounds in exhaled air from mass spectrometry, at hospitalisation, post-hospitalisation and follow-up consultation in patients infected by COVID-19 and recovered.

    Time frame: 4 months

07

Study locations

1 site
  • Hôpital Foch
    Suresnes, France
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 27, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT04379154
Lead sponsor
Hopital Foch
Responsible party
Sponsor
First posted
May 7, 2020
Start date
Apr 14, 2020
Primary completion
Jun 1, 2021
Completion
Jun 1, 2021
Last update
Jan 27, 2022

Study contacts

Hélène Salvator
principal investigator · Pneumology unit

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2022. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion