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CompletedNCT04359173HMPUpdated Apr 24, 2020

Propensity Score Matched Comparison of HMP vs. SCS in Kidney Transplantation

An observational study in Delayed Graft Function, sponsored by Medical University Innsbruck. Completed at 1 site in Austria. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-04-24.

Sponsored by Medical University Innsbruck · Observational

Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
347
Ages
18 Years and older
Sex
All
01

Study summary

Hypothermic machine perfusion (HMP) is considered superior to static cold storage (SCS) in kidney transplantation, but the true benefit in the real-world experience remains incompletely understood.

The aim of our study is to investigate the real-world impact of HMP on kidney graft function after deceased donor kidney transplant in an HMP cohort propensity score matched with SCS.

Propensity score matching will be based on CIT, ECD, gender mismatch, CMV mismatch, re-TX and ET-senior program with a caliper of 0.05

02

Conditions studied

  • Delayed Graft Function

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Keywords

  • kidney transplantation
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In context

Delayed Graft Function

83 studies on the registry are indexed under Delayed Graft Function; 15 are open to participants now.

This study's enrollment of 347 is above the median of 125 across 16 observational studies indexed under Delayed Graft Function.

Browse Delayed Graft Function studies →

Lead sponsor

Medical University Innsbruck is the lead sponsor of 186 studies on the registry; 47 are open to participants now.

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Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

All deceased donor kidney transplants performed between 08/2015 and 12/2019

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • single kidney transplantation from a deceased donor at Medical University of Innsbruck between 08/2015 and 12/2019

Exclusion criteria

Exclusion Criteria:

  • combined kidney transplantation with an other organ
  • living donor kidney transplantation
05

Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
347 participants (actual)
Patient registry
No

Groups and cohorts

  • Hypothermic machine perfusion (HMP)

    patients who underwent kidney transplantation following HMP

  • Static cold storage (SCS)

    patients who underwent kidney transplantation following SCS

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What researchers measure

Primary outcomes

  1. Delayed graft function (DGF)

    DGF was defined as the need for at least one dialysis within the first seven days after transplant with the exception of dialysis for hyperkalemia or hypervolemia within the first 12 hours post-transplant

    Time frame: 7 days post transplant

Secondary outcomes

  1. graft survival

    24 month graft survival

    Time frame: 24 months post transplant

07

Study locations

1 site
  • Medical University of Innsbruck
    Innsbruck, Tyrol 6020, Austria
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Aug 2015 to primary completion in Dec 2019, 52 months.

How these figures are worked out, and which studies are left out of them.

Registered
Apr 20, 2020
First posted
Apr 24, 2020
StartActual
Aug 1, 2015
Primary completionActual
Dec 31, 2019
CompletionActual
Mar 30, 2020
Last update
Apr 24, 2020
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 24, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04359173
Lead sponsor
Medical University Innsbruck
Responsible party
Sponsor
First posted
Apr 24, 2020
Start date
Aug 1, 2015
Primary completion
Dec 31, 2019
Completion
Mar 30, 2020
Last update
Apr 24, 2020

Study contacts

Stefan Schneeberger, Prof.
principal investigator · Medical University of Innsbruck

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.

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Discussion

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