An interventional study of Oat Bran Consumption in Human Health, Polyphenols and Pharmacokinetics, sponsored by North Carolina Agriculture & Technical State University. Completed. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-08-06.
Sponsored by North Carolina Agriculture & Technical State University · Not applicable, Interventional, and Basic science
Avenanthramides and saponins are types of chemical compounds found naturally in oats.
Avenanthramides have anti-oxidant properties, anti-atherosclerotic, anti-inflammation, and anti-proliferative effects on cancer cells in vitro. Oat saponins, or avenacosides, have the ability to bind cholesterol, and thus, the ability to lower blood cholesterol.
Oat bran is a known source of these dietary compounds. This study aims to determine the bioavailability of these compounds to in the urine of participants after ingesting an oat bran cereal, both before, and after for multiple time points.
Analytical chemistry will be used to determine the bioavailability of the oat compounds at each time point. This will help to establish a kinetic curve for the metabolism of these compounds.
Initially, the diet of the participants will be asked to restricted to avoid eating any polyphenols that might interfere with the employed analytical chemistry techniques. This period of diet restriction is the washout period. The list of foods to avoid are: oats, whole grains, fruits, vegetables, herbal supplements, ginger, coffee, tea, and chocolate.
After the washout period, a baseline urine and fecal sample will be collected from the participants, then a large portion of oat bran will be provided to the participants for consumption. The approximate portion size will be 100 g by dry weight. The participants will then provide urine samples during the designated time points. The time points for the urine collection are as follows:
North Carolina Agriculture & Technical State University is the lead sponsor of 9 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Each subject consumed 120 g of oat bran (by dry weight) in a single dose, and samples (urine and fecal) were collected at different time points following the administration of oat bran.
Dietary Supplement: Oat Bran Consumption
Oat bran (120 g), single dose.
Also known as: Gut Microbiome and Oat metabolism Study
Bioavailability of Avenanthramides and Saponins in Urine
Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine.
Time frame: 0-2 hours post-dose
Bioavailability of Avenanthramides and Saponins in Urine
Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine.
Time frame: 2-4 hours post-dose
Bioavailability of Avenanthramides and Saponins in Urine
Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine.
Time frame: 4-6 hours post-dose
Bioavailability of Avenanthramides and Saponins in Urine
Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine.
Time frame: 6-9 hours post-dose
Bioavailability of Avenanthramides and Saponins in Urine
Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine.
Time frame: 9-12 hours post-dose
Bioavailability of Avenanthramides and Saponins in Urine
Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine.
Time frame: 12-24 hours post-dose
Bioavailability of Avenanthramides and Saponins in Urine
Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine.
Time frame: 24-32 hours post-dose
Bioavailability of Avenanthramides and Saponins in Urine
Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine.
Time frame: 32-48 hours post-dose
No study locations are listed for this record.
This study is completed, as verified in Aug 2020. You cannot join it, but the record below documents what was studied.
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North Carolina Agriculture & Technical State University