An observational study in Autism-Spectrum Disorder and Conduct Disorder, sponsored by University Hospital, Basel, Switzerland. Status unknown at 1 site in Switzerland. Open to participants aged 10 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-03-02.
Sponsored by University Hospital, Basel, Switzerland · Observational
This study is
Differences in emotion processing and the underlying neural underpinnings of such differences will be assessed by means of functional magnetic resonance imaging (fMRI) without any contrast agent, combined with adapted emotion processing paradigms and eye tracking techniques.
117 studies on the registry are indexed under Child Development Disorders, Pervasive; 15 are open to participants now.
This study's planned enrollment of 120 is close to the median of 125 across 26 observational studies indexed under Child Development Disorders, Pervasive.
Browse Child Development Disorders, Pervasive studies →University Hospital, Basel, Switzerland is the lead sponsor of 990 studies on the registry; 189 are open to participants now.
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German speaking children and adolescents (10-18 years of age) attended at the Kinder- und Jugendpsychiatrischen Klinik Basel (KJPK) and with a confirmed diagnosis of CD or ASD.
Typically developing children will be recruited using leaflets (will be distributed in the KJPK clinics and in socioeconomically diversesecondary schools within the Canton of Basel-Stadt).
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
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Contraindication
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children and adolescents with CD
Other: neuroimaging session (with simultaneously acquired eye-tracking) · Other: Questionnaire (for children) assessing traumatic experiences (Childhood trauma questionnaire (CTQ)) · Other: Social and Health Assessment (SAHA) questionnaire (for children) · Other: Massachusetts Youth Screening Instrument (MAYSI-2) (for children) · Other: Interpersonal Reactivity Index (IRI) (for children) · Other: Youth Psychopathic Traits Inventory (YPI) (for children) · Other: Reactive Proactive Questionnaire (RPQ) (for children) · Other: Emotion Regulation Questionnaire (for children) · Other: Basic Empathy Scale (BES) (for children) · Other: Pubertal Development Scale (PDS) (for children) · Other: Alabama Parenting Questionnaire (APQ) (for parents) · Other: Inventory of Callous Unemotional Traits (ICU) (for parents) · Other: Child Behavior Checklist (CBCL) (for parents) · Other: Griffith Empathy Measure (GEM) (for parents) · Other: Social Responsiveness Scale (SRS) (for parents)
children and adolescents with ASD
Other: neuroimaging session (with simultaneously acquired eye-tracking) · Other: Questionnaire (for children) assessing traumatic experiences (Childhood trauma questionnaire (CTQ)) · Other: Social and Health Assessment (SAHA) questionnaire (for children) · Other: Massachusetts Youth Screening Instrument (MAYSI-2) (for children) · Other: Interpersonal Reactivity Index (IRI) (for children) · Other: Youth Psychopathic Traits Inventory (YPI) (for children) · Other: Reactive Proactive Questionnaire (RPQ) (for children) · Other: Emotion Regulation Questionnaire (for children) · Other: Basic Empathy Scale (BES) (for children) · Other: Pubertal Development Scale (PDS) (for children) · Other: Alabama Parenting Questionnaire (APQ) (for parents) · Other: Inventory of Callous Unemotional Traits (ICU) (for parents) · Other: Child Behavior Checklist (CBCL) (for parents) · Other: Griffith Empathy Measure (GEM) (for parents) · Other: Social Responsiveness Scale (SRS) (for parents)
typically developing adolescents
Other: neuroimaging session (with simultaneously acquired eye-tracking) · Other: Questionnaire (for children) assessing traumatic experiences (Childhood trauma questionnaire (CTQ)) · Other: Social and Health Assessment (SAHA) questionnaire (for children) · Other: Massachusetts Youth Screening Instrument (MAYSI-2) (for children) · Other: Interpersonal Reactivity Index (IRI) (for children) · Other: Youth Psychopathic Traits Inventory (YPI) (for children) · Other: Reactive Proactive Questionnaire (RPQ) (for children) · Other: Emotion Regulation Questionnaire (for children) · Other: Basic Empathy Scale (BES) (for children) · Other: Pubertal Development Scale (PDS) (for children) · Other: Alabama Parenting Questionnaire (APQ) (for parents) · Other: Inventory of Callous Unemotional Traits (ICU) (for parents) · Other: Child Behavior Checklist (CBCL) (for parents) · Other: Griffith Empathy Measure (GEM) (for parents) · Other: Social Responsiveness Scale (SRS) (for parents)
neuroimaging session, including two functional neuroimaging paradigms (ca. 15-20 minutes each) and a short structural image acquisition (mprage) for coregistration. Functional Magnetic Brain Imaging (fMRI) and simultaneous eye-tracking data will be collected during the paradigms: 1) an emotion processing paradigm (adapted from Passamonti et al., 2010); and 2) an emotional Go/noGo paradigm (adapted from Hare et al., 2008).
The Childhood Trauma Questionnaire is a brief survey of six early traumatic experiences (death, divorce, violence, sexual abuse, illness or other), and assesses individual's understanding of their childhood trauma.
Self reported survey assessing social and mental health with four aspects of parenting determined (parental involvement, parental warmth, parental control, and inconsistency of parenting).
The Massachusetts Youth Screening Instrument (MAYSI-2) is a screening instrument developed for detecting mental health needs in youth aged 12-17. Designed as a low-cost, easily administered tool, it screens for multiple issues and can be administered in 10-15 minutes. It is divided into seven scales composed of 52 questions that are designed to detect alcohol/drug use, angryirritable behavior, depression-anxiety, somatic complaints, suicide ideation, thought disturbance, and traumatic experience. Youths answer YES or NO concerning whether each item has been true for them "within the past few months.
The Interpersonal Reactivity Index is a measure of dispositional empathy that takes as its starting point the notion that empathy consists of a set of separate but related constructs. The instrument contains four seven-item subscales (seven Likert items each), each tapping a separate facet of empathy (Empathic Concern, Perspective Taking, Personal Distress, and Fantasy). The 28-item IRI contains four subscales
self-report screening measures to assess psychopathic traits in youth assessing 10 core personality traits associated with the construct (grandiosity, lying, manipulation, callousness, unemotionality, impulsivity, irresponsibility, dishonest charm, remorselessness, and thrill seeking). Each item is scored on an ordinal 4-point Likert scale (1 = Does not apply at all, to 4 = Applies very well). Higher scores reflect an increased presence of psychopathic traits.
The Reactive-Proactive Questionnaire (RPQ) scores (0 (never), 1 sometimes, 2 (often)) for proactive aggression items and reactive items. Proactive and reactive scale scores are summated to obtain total aggression scores.
10-item scale designed to measure respondents' tendency to regulate their emotions in two ways: (1) Cognitive Reappraisal and (2) Expressive Suppression. Respondents answer each item on a 7-point Likert-type scale ranging from 1 (strongly disagree) to 7 (strongly agree)
The Basic Empathy Scale (BES) measures 20 items (affective and cognitive empathy) on a Five-point Likert-type scale.
self-report measure of physical development which has been shown to be correlated with measures of pubertal development derived from physical examination. Responses are coded on 4-point scales (1 = no development and 4 = completed development). For girls, a yes-no question about onset of menarche is weighted more heavily (1 = no and 4 = yes). For both genders, ratings are then averaged to create an overall score for physical maturation.
The APQ measures five dimensions of parenting that are relevant to the etiology and treatment of child externalizing problems: (1) positive involvement with children, (2) supervision and monitoring, (3) use of positive discipline techniques, (4) consistency in the use of such discipline and (5) use of corporal punishment (42 self-reported responses, rated on a 5-point Likert scale- 1 (never) to 5 (always) for both child and parent forms)
24-item questionnaire designed to provide a comprehensive assessment of callous and unemotional traits.The ICU has three subscales: Callousness, Uncaring, and Unemotional. The ICU is made up of statements with a 4-point Likert scale, ranging from 0 (Not at all true) to 3 (Definitely True), with higher scores indicating greater CU traits.
The eight empirically-based syndrome scales are: 1. Aggressive Behavior 2. Anxious/Depressed 3. Attention Problems 4. Rule-Breaking Behavior 5. Somatic Complaints 6. Social Problems 7. Thought Problems 8. Withdrawn/Depressed. Higher scores indicate greater Problems.
self-report 23-item measure of empathy in which the respondent answers each item on a nine-point Likert scale from strongly disagree to strongly agree
Social Responsiveness Scale (SRS) measures social ability of children from 4 years to 18 years old. It is used primarily with individuals with Autism Spectrum Disorder (ASD), family members of individuals with ASD, and others who have social impairments. Parent or teacher questionnaire (65 items on a 4-point Likert scale). High scores are associated with more severe social impairments.
difference between groups (children and adolescents with CD, ASD and typically developing adolescents) in neural activity
difference between groups in neural activity as measured by Blood Oxygen Level Dependent (BOLD) signal during emotion processing using a priori defined regions of interest (ROIs) including the insula, amygdala, and ventromedial prefrontal Cortex in fMRI
Time frame: fMRI imaging Day 1
Emotion processing task (fMRI)
Emotion processing task (fMRI): measures of eye gaze collected by eye-tracking
Time frame: fMRI imaging Day 1
This study is status unknown, as verified in Feb 2022. You cannot join it, but the record below documents what was studied.
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Child Development Disorders, Pervasive →
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