An interventional study of Control and Hesperidin in Higher Uric Acid Concentrations (>5,5 mg/dl) and Healthy, sponsored by University of Kiel. Completed at 1 site in Germany. Open to participants aged 20 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-07-03.
Sponsored by University of Kiel · Not applicable, Interventional, and Basic science
Aim of the study is to investigate the impact of hesperidin and/or vitamin C on elevated uric acid concentrations.
Duration of the study is 9 weeks. 1) a washout week, 2) two intervention weeks, 3) four weeks washout period, 4) two intervention weeks.
The study is conducted under free living conditions. During washout weeks consumption of orange juice or citrus fruits or vitamin C containing supplements is restricted.
During intervention weeks 200 mL of study drink is consumed daily. And participants are asked to maintain their normal physical activity and habitual diet. Additional citrus or vitamin C containing beverages are not allowed.
At the beginning and the end of each intervention phase uric acid, insulin sensitivity, blood pressure, pulse wave velocity and bioavailability of hesperidin are assessed.
University of Kiel is the lead sponsor of 25 studies on the registry; 6 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
study drink without hesperidin and without vitamin C compared to study drink with hesperidin
Dietary Supplement: Control · Dietary Supplement: Hesperidin
study drink with vitamin C compared to study drink with hesperidin and vitamin C
Dietary Supplement: Vitamin C · Dietary Supplement: Hesperidin + Vitamin C
study drink (two weeks)
study drink + Hesperidin 600 mg (two weeks)
study drink + Vitamin C 250 mg (two weeks)
study drink + Hesperidin 600 mg + Vitamin C 250 mg (two weeks)
Changes in uric acid serum concentrations
measured via uric acid serum concentration (mg/dL)
Time frame: Baseline (pre) and post two weeks of intervention
changes in uric acid excretion
measured via uric acid excretion in 24h urine (mg/24h)
Time frame: Baseline (pre) and post two weeks of intervention
changes in pulse wave velocity
measured via oscillometric method (m/s)
Time frame: Baseline (pre) and post two weeks of intervention
insulin sensitivity
measured via minimal model from oral glucose tolerance test data using the particular study drink with added glucose to 75 g Glucose / 200 mL
Time frame: Baseline (pre) intervention periods
bioavailability of hesperidin in blood
detection of hesperidin metabolites measured via chromatography and following mass spectrometry in serum
Time frame: Baseline (pre) and post two weeks of intervention
bioavailability of hesperidin in urine
detection of hesperidin metabolites measured via chromatography and following mass spectrometry in 24h urine
Time frame: Baseline (pre) and post two weeks of intervention
This study is completed, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.
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University of Kiel