An observational study in Muscle Function, sponsored by Sheffield Teaching Hospitals NHS Foundation Trust. Completed at 1 site in United Kingdom. Open to female participants aged 60 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-11-18.
Sponsored by Sheffield Teaching Hospitals NHS Foundation Trust · Observational
Growing evidence suggests that dynapenic abdominal obesity is associated with a greater risk of falls, functional disability and hospitalisation compared to those with dynapenia, obesity or neither phenotype. Understanding the pathogenesis underlying this phenotype has the potential to inform potential treatment strategies.
MicroRNAs can act as messengers at the cellular level to promote or block processes for muscle growth and repair, amongst other things. There is evidence that ageing changes microRNA levels in the muscle and that these changes may result in reduced muscle quality and quantity. However, it is not known whether being obese can change microRNA levels in muscle and how this relates to physical performance.
The aim of this study is to investigate the effect of dynapenic abdominal obesity on microRNA levels in serum and muscle quality and quantity in the legs of older women.
This is an observational, cross-sectional study. The investigators will recruit 4 groups of older women: normal weight, normal weight with dynapenia, obese and obese with dynapenia. The investigators will measure the microRNA levels in serum. The investigators will measure the quantity and fat content of muscle in the legs using magnetic resonance imaging. Muscle strength, fatigue and balance will be measured using gait (walking) analysis, balance tests, and a machine designed to measure leg strength and fatigue.
The investigators will measure and compare microRNA levels between groups. The investigators will use databases and computer programmes to look at all of the microRNAs which are different between groups and see how they affect the muscle. The investigators will compare muscle strength, size and fatigue between groups. The investigators will explore relationships of muscle quantity and quality measures with microRNA changes in the muscle. This approach will allow the investigators to understand how obesity affects the microRNA profile of muscle and whether this translates into impairment of function and mobility.
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's enrollment of 30 is below the median of 135 across 1,283 observational studies indexed under Obesity.
Browse Obesity studies →Sheffield Teaching Hospitals NHS Foundation Trust is the lead sponsor of 207 studies on the registry; 26 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Healthy Caucasian Women Recruited from around South Yorkshire and Merseyside, UK
Exclusion Criteria:
History of current conditions which may affect muscle metabolism
Use of medications or treatment known to affect muscle metabolism
o Anabolic steroids, glucocorticoids, antiretrovirals etc.
BMI 18.5 to 25kg/m2, waist circumference \<= 88cm, healthy women aged 60-80 years, time to complete 5 chair stands \<15 seconds
Other: observational study
BMI 18.5 to 25kg/m2, waist circumference \<= 88cm,healthy women aged 60-80 years, time to complete 5 chair stands \>15 seconds
Other: observational study
BMI 30 to 40kg/m2, waist circumference \> 88cm, healthy women aged 60-80 years, time to complete 5 chair stands \<15 seconds
Other: observational study
BMI 30 to 40kg/m2, waist circumference \> 88cm, women aged 60-80 years, time to complete 5 chair stands \>15 seconds
Other: observational study
observational study
Differential microRNA expression, expressed as fold-change and p-values, measured using real time quantitative polymerase chain reaction (RT-qPCR) between normal weight and obese groups, further stratified by dynapenia
Serum analyses
Time frame: 1 day (one measurement )
mean difference in distance walked during 6 minute walk test between normal weight and obese, further stratified by dynapenia
6 Minute walk test
Time frame: 1 day (one measurement )
mean difference in muscle mass and volume measures between normal weight and obese, further stratified by dynapenia MRI
MRI (Magnetic Resonance Imaging)
Time frame: 1 day (one measurement )
mean difference in muscle mass and volume measures between normal weight and obese, further stratified by dynapenia DXA
DXA (dual energy X-ray absorptiometry)
Time frame: 1 day (one measurement )
mean difference in muscle strength between normal weight and obese, further stratified by dynapenia
Isokinetic dynamometer
Time frame: 1 day (one measurement )
mean difference in fatigue between normal weight and obese, further stratified by dynapenia
kinetic change in gait parameters from Opal accelerometers
Time frame: 1 day (one measurement )
This study is completed, as verified in Nov 2023. You cannot join it, but the record below documents what was studied.
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Sheffield Teaching Hospitals NHS Foundation Trust