CClinicalTrials.gg
CompletedNCT04258826Updated Feb 22, 2022

A Study to Evaluate LY3154207 on the Brain of Healthy Participants

A Phase 1 interventional study of LY3154207 and Placebo in Healthy, sponsored by Eli Lilly and Company. Completed at 1 site in United States. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-02-22.

Sponsored by Eli Lilly and Company · Phase 1, Interventional, and Basic science

From the registry’s dates

  • Primary completion was Jan 2022, 4 years 8 months ago, and no results have been posted to the registry.
Phase
Phase 1
Study type
Interventional
Enrollment
16
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

The purpose of this study is to learn more about how LY3154207 affects the brain of healthy participants by using magnetic resonance imaging. The study will last up to about nine weeks for each participant and may include up to four visits to the study center.

02

Conditions studied

  • Healthy
03

In context

Lead sponsor

Eli Lilly and Company is the lead sponsor of 2,048 studies on the registry; 140 are open to participants now.

Of its 521 completed or terminated interventional studies of FDA-regulated products, 341 (65%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

-Overtly healthy males and non-childbearing females, as determined through medical history and physical examination

Exclusion criteria

Exclusion Criteria:

  • Have known or ongoing psychiatric disorders
  • Have contraindications to magnetic resonance imaging (MRI)
05

Study design

Phase
Phase 1
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Investigator)
Enrollment
16 participants (actual)

Study arms

  • Experimental
    LY3154207

    LY3154207 administered orally in one of two study periods.

    Drug: LY3154207

  • Placebo comparator
    Placebo

    Placebo administered orally in one of two study periods.

    Drug: Placebo

Interventions

  • DrugLY3154207

    LY3154207 administered orally.

  • DrugPlacebo

    Placebo administered orally.

06

What researchers measure

Primary outcomes

  1. Change from Baseline in Intrinsic Functional Connectivity Among Resting-State Networks of the Brain

    Mean Connectivity and Mean Component Weight Between LY3154207 and Placebo in the Dorsal Attention Network (DAN), Frontoparietal Network (FPN), and Executive Control Network (ECN).

    Time frame: Day 1, Approximately Day 28

07

Study locations

1 site
  • Northwestern University
    Chicago, Illinois 60659, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 22, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04258826
Lead sponsor
Eli Lilly and Company
Responsible party
Sponsor
First posted
Feb 6, 2020
Start date
Jan 15, 2021
Primary completion
Jan 28, 2022
Completion
Jan 28, 2022
Last update
Feb 22, 2022

Study contacts

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
study director · Eli Lilly and Company

Oversight

Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2022. You cannot join it, but the record below documents what was studied.

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