Lumenato Nutritional Supplement on Skin Appearance

• Resides in the United States
• Generally healthy women between the ages of 35-55
• Fitzpatrick skin types 2 or 3
• Identifies as one of the following: Asian, White, Hispanic/Latino, or both White and Hispanic/Latino
• Type 2 on the Glogau Skin Classification scale
• Has expressed interest in improving skin health and appearance
• Willing and able to follow the procedures of the study
• Willing to refrain from changing their diet or lifestyle significantly for the duration of the study
• Able to understand the study requirements and activities in English, and provide informed consent
• Access to reliable internet service and smartphone in order to utilize the ClaimIt software/app needed to remotely participate in the study

Exclusion Criteria:

• Participants with Fitzpatrick skin types of 1, 4, 5 or 6
• Known allergies or sensitivity to tomato, latex and/or potato
• Current use or use within 1 month of study enrollment of hormonal therapies (including hormonal contraceptives)
• Current, regular use or regular use within 1 month of study enrollment of oral steroids; regular use defined as >10 consecutive days
• Chronic or relapsing inflammatory and/or allergic skin conditions such as atopic dermatitis, rosacea, psoriasis and alike including telangiectasias ("spider veins")
• Pregnant, lactating or breastfeeding women (within the last 6 months) or those planning to become pregnant during the study period
• Less than 2 years since diagnosis or treatment of skin cancer including basal cell carcinoma, squamous cell carcinoma, melanoma- excluding actinic keratosis
• Currently active herpes infections or currently on treatment for herpes infections
• History of facial keloids
• Current diagnosis of adult acne or currently on treatment for adult acne
• Recent (\<6 months at enrollment) cardiovascular conditions such as stroke, transient ischemic attack (TIA), or myocardial ischemia/infarction, recently on treatment for congestive heart failure, or currently having vasculitis or vascular conditions
• On potent blood thinners such as low-molecular weight heparin (LMWH), rivaroxaban, apixaban, or other prescription blood thinners - excludes aspirin
• Holds a current diagnosis of diabetes mellitus type I or II
• Participants who have received facial irradiation within last year or are planning on undergoing facial irradiation during the study
• Chronic liver disease- excluding early stage non-alcoholic fatty liver disease (NAFLD)
• Chronic kidney disease or recent (\<6 months at enrollment) acute kidney disease
• Participants who currently take supplements containing carotenoids, lutein, melatonin or tryptophan
• Participants with occupations or lifestyle that require significant daily exposure to the sun (defined as at least 1 hour of continuous outdoor sun exposure)
• Participants who have had a sunburn in the last 2 weeks
• Participants who use tanning salons or tanning products in the last 3 months
• Participants who plan to undergo invasive facial procedures (injections, chemical peeling, etc.) during the study or have undergone these procedures within 2 months prior to enrollment
• Change in oral supplements or medications targeting skin health within 2 months prior to enrollment
• Participants who are HIV positive
• Participants who are immunosuppressed
• Participants with a recent (\<2 months prior to enrollment) diagnosis of a psychiatric condition
• Participants having chronic connective tissue disorder affecting the skin (e.g. Ehlers- Danlos syndrome, Marfan's Syndrome, Osteogenesis Imperfecta)
• Participants with auto-immune skin diseases (e.g. scleroderma, psoriasis, lupus, epidermolysis bullosa, bullous pemphigoid, temporal arteritis)
• Participants who have been prescribed retinoids treatment (\<2 months prior to enrollment)
• Participants who meet either/or both of the following criteria with regards to smoking habits (smoking includes cigarettes, e-cigs, pipes, hookah, cigars):
• Who are current smokers (smoked at least 100 cigarettes, or tobacco/nicotine equivalent, in her lifetime) and who continue to use these products
• Who were former smokers (smoked at least 100 cigarettes, or tobacco/nicotine equivalent, in her lifetime, but who have quit smoking) who have smoked within the last year and/or were former smokers for 10 years
• Participants who drink more than 14 drinks per week (more than 2 drinks per night)
• Participants who use illicit or illegal drugs
• Participants who are regular users of cannabis substances or substances derived from cannabis such as CBD, CBD oils or balms, cannabis-containing edibles; vaping; smoking; hookahs.
• NOTE: regular use is defined as long stretches of inhaling or consuming these products over several months or longer. Occasional, but not weekly, use of products with small amounts of CBD-related compounds (e.g. waters with CBD infusions) are not considered regular use.)
• Participants who are planning a trip to the mountains or to a higher UV index region during the study period
• Any other medication, condition or disease that in the PI's opinion that may adversely affect the participant's ability to complete the study, substantially impact the study's integrity or may pose a significant risk to the participant
• Participants who are experiencing perimenopausal or menopausal symptoms
• Participants who have had a hysterectomy and/or both of their ovaries removed