An interventional study of intramuscular progesterone 20-40mg from D3 until pregnancy test in Progesterone,Hormone Replacement Thawed Embryo Transfer Cycles, sponsored by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University. Status unknown. Open to female participants aged 20 Years to 41 Years. Per ClinicalTrials.gov, last updated 2020-01-30.
Sponsored by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Not applicable, Interventional, and Treatment
In the window of implantation, progesterone plays an important role. Sufficient serum progesterone is basic for ongoing pregnancy. Vaginal progesterone is more and more widely used in ART. As it has no hepatic first pass effect. What is the optimal serum level for pregnancy when use vaginal progesterone is not known yet? Hormone replacement therapy- FET is the optimal strategy to explore this question. There are some retrospective studies showed that the serum progesterone level on embryo transfer day (D3 or D5) or pregnancy test day (D14) lower than 10-11ng/ml is significantly associated with ongoing pregnancy rate in HRT-FET cycles. This prospective study is designed to compare the ongoing pregnancy rate between different serum progesterone levels on D3 and to explore the intervention of additional progesterone supplement since D3 is helpful in HRT-FET cycles.
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University is the lead sponsor of 466 studies on the registry; 271 are open to participants now.
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Exclusion Criteria:
The included patient should test serum progesterone level on D3 no matter which day perform the embryo transfer. According to the progesterone level, there are two groups, Group A: serum progesterone \<7.24ug/L, followed by randomized A1: plus additional treatment（intramuscular progesterone 20-40mg from D3 ）
Drug: intramuscular progesterone 20-40mg from D3 until pregnancy test
The included patient should test serum progesterone level on D3 no matter which day perform the embryo transfer. According to the progesterone level, there are two groups, Group A: serum progesterone \<7.24ug/L, followed by randomized A2：without additional treatment
Group B：serum progesterone ≥7.24ug/L， without additional treatment
serum progesterone \<7.24ug/L, followed by randomized A1: plus additional treatment（intramuscular progesterone 20-40mg from D3 ）
Ongoing pregnancy rate
beyond pregnancy week 12 in HRT-FET cycles
Time frame: 10 weeks after embryo transfer
Clinical pregnancy rate
intrauterine gestational sacs by ultrasound
Time frame: 10 weeks after embryo transfer
No study locations are listed for this record.
Plan to share: Undecided
This study is status unknown, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University