An interventional study of Exercise Therapy in Lung Transplantation, sponsored by University Hospital A Coruña. Status unknown. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-01-29.
Sponsored by University Hospital A Coruña · Not applicable, Interventional, and Treatment
Lung Transplantation is usually the last option for patients with chronic respiratory conditions in the late stages of the disease. Pulmonary rehabilitation and, particularly, endurance training, is a cornerstone in the management of these patients both during the pre-operative as well as the post-operative period as it improves cardiopulmonary fitness, muscle mass, muscle strength, health-related quality of life and potentially, survival. However, very few studies have been published addressing which modality of training, intensity, frequency or duration of training provides the best possible results in these patients. Therefore, the objective of this study was to compare two training modalities (treadmill walking versus cycle-ergometry) on functional capacity, muscle strength and lung function.
University Hospital A Coruña is the lead sponsor of 7 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants in the treadmill training group will perform endurance training during the post-operative period using a treadmill (Salter Housewares, UK) for a minimum of 20 sessions. Intensity of training will be set according to 80% of the mean speed achieved during the 6MWT for a targeted time of 30 minutes. Intensity and duration will be adapted to the participant's physical condition, especially during the first week. After the endurance training, participants will perform resistance training for 20 - 30 minutes for conditioning of the main muscles in the upper and lower limbs using elastic bands, dumbbells and body-weight exercises. Intensity will progressively increase up to 70% of the maximum isometric strength measured with a hand-held dynamometer. Volume of training will also increase from 1 to 3 sets of 12 repetitions each. When needed patients will also be taught breathing exercises and airway clearance techniques.
Other: Exercise Therapy
Participants in this group will perfom endurance training during the post-operative period using a cycle ergometer (Monark 828e, Monark AB, Sweeden) for a minimum of 20 sessions. Intensity of training will be set according to the results of a symptom-limited incremental cycle-ergometry test performed on the first day to achieve 80% of the maximal workload obtained for a targeted time of 30 minutes. Intensity and duration will be adapted to the participant's physical condition, especially during the first week. Participants in this group will also perfom resistance training and breathing exercises as in the treadmill training group.
Other: Exercise Therapy
Endurance training in the form of treadmill/cycle-ergometry
6 Minute Walk Test
Distance covered during the 6 Minute Walk Test performed according to the American Thoracic Guidelines.
Time frame: 1 month
6 Minute Walk Test
Distance covered with the 6 Minute Walk Test performed according to the American Thoracic Guidelines.
Time frame: 3 Months
Maximal isometric strength
Isometrical maximal strength of the brachial biceps and quadriceps muscle of both dominant and non-dominant limbs. Maximal isometric strength will be assessed using a hand-held dynamometer (Lafayette Instrument, Model 01165) and will be presented in kilograms
Time frame: 1 and 3 months
Sit-to-stand
Number of times the patient can stand up from a chair and sit back in 30 seconds
Time frame: 1 and 3 months
Forced Expiratory Volume 1st second (FEV1)
Changes in Forced Expiratory Volume in the 1st second assessed during a forced spirometry test performed according to the international guidelines.
Time frame: 1 and 3 months
Incremental Symptom-Limited Test
Incremental symptom-limited test performed on a cycle-ergometry with a 5-10W increase per minute up to maximal tolerance. Patient was monitorised during the test for both heart rate and oxygen saturation.
Time frame: 1 and 3 months
Maximal inspiratory and expiratory pressures
Maximal inspiratory and expiratory pressures performed with the respiratory muscles
Time frame: 1 and 3 months
Forced Expiratory Capacity (FVC)
Changes in forced expiratory capacity assessed during a forced spirometry test performed according to the international guidelines.
Time frame: 1 and 3 months
Peak Expiratory Flow (PEF)
Changes in peak expiratory flow assessed during a forced spirometry test performed according to the international guidelines.
Time frame: 1 and 3 months
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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University Hospital A Coruña