An interventional study of Prolonged Exercise session in Healthy, sponsored by Universidad Europea de Madrid. Completed at 1 site in Spain. Open to male participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-06-22.
Sponsored by Universidad Europea de Madrid · Not applicable, Interventional, and Basic science
The aim of this project is to study the effect of a bout of exercise on the metabolomic profile of plasma and feces as well as its influence on the intestinal microbiota.
The practice of physical exercise has numerous health benefits, preventing the appearance and development of cardiovascular diseases and various types of cancer. Exercise causes changes in the vascular, muscular and pulmonary systems, etc. One of the benefits that can result from exercise modification of the intestinal microbiota and its metabolic profile. In order to identify the potential changes that exercise has on the intestinal microbiota and its metabolic profile, the purpose of this study is to identify changes in the plasma and fecal metabolome and in fecal microbiota associated with a bout of exercise
Universidad Europea de Madrid is the lead sponsor of 99 studies on the registry; 23 are open to participants now.
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Exclusion Criteria:
Participants will exert an exercise prolonged session
Other: Prolonged Exercise session
After a standardized warm-up of 10 minutes of continuous running on a treadmill at 60% of their maximum heart rate (HRmax), subjects will perform a maximum oxygen consumption test (VO2max) with a gas analyzer (UltimaTM Series, MGC Diagnostic Corporation, St. Paul, MN, USA. The protocol will start with a slope of 1% at a speed of 10 km/h, with increments of 0.3 km/h every 30 s until volitional exhaustion. Finally, ten minutes after the treadmill test, volunteers will run 1 kilometer (t1km) as fast as possible and the time needed to cover the distance will be recorded.
Plasma metabolome profile
Abundance of blood metabolites, metabolic networks, and metabolic pathways activity
Time frame: Changes from baseline to 30 min after the exercise intervention
Fecal microbiota
Abundance of gut microbial taxa, communities, and metabolic pathways activity
Time frame: Changes from baseline to 30 min after the exercise intervention
Plan to share: Yes — All IPD that underlie results in a publication. Metagenomic raw data will be deposited in the http://www.ncbi.nlm.nih.gov/sra
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
Time frame: Upon publication
Access criteria: Data will be in a public repository
No publications or documents are linked to this record.
Ran from Feb 2020 to primary completion in Mar 2020, 0 months.
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This study is completed, as verified in Jun 2020. You cannot join it, but the record below documents what was studied.
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Universidad Europea de Madrid