An interventional study of nasal brushing and bacteriological sample in Chronic Rhinosinusitis (Diagnosis), sponsored by Centre Hospitalier Intercommunal Creteil. Withdrawn at 2 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-12.
Sponsored by Centre Hospitalier Intercommunal Creteil · Not applicable, Interventional, and Diagnostic
Impact of chronic rhinosinusitis on the index of ciliary beat efficiency using fluorescent nanosticks
To date, the assessment of ciliary beat is only possible ex vivo on epithelial cells obtained from upper airway brushing. A previous prospective study (I-IsBac) showed a change in ciliary beat (in terms of coordination and frequency) in bacterial rhinosinusitis. The study of ex-vivo ciliary movement appears to be an interesting tool to understand the pathophysiology of CSRs and to guide and evaluate treatment.
A new tool to evaluate the effectiveness of the ex-vivo lash beat has been developed. This tool measures shear stress by tracking balls along the ciliary margin.
This measurement of ex-vivo shear stress by bead tracking is a validated technique. However, microbead tracking is limited by its low spatial and temporal resolution, long measurement time and heavy post-processing of acquisition data, making this method difficult to use in clinical routine. Monitoring ex-vivo fluorescent nano-batons could represent a simpler alternative for the clinician. This measurement is now made possible by Phosphate Lanthanum Lanthanum Nano-batons (LaPO4) whose luminescence is directly proportional to the shear.
The objective of this research project is to validate this new tool in patients with CSR by comparing it to a group of control subjects free of nasal inflammation.
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Patient ≥ 18 years old
Exclusion Criteria:
Patients with endonasal surgery scheduled under general anesthesia for an indication of Chronic Rhinosinusitis (CRS)
Procedure: nasal brushing and bacteriological sample
Patients with endonasal surgery scheduled under general anesthesia for an indication of endonasal surgery for nasal obstruction or patients requiring an endonasal surgical approach such as pituitary adenomas for example.
Procedure: nasal brushing and bacteriological sample
A nasal brushing as well as a bacteriological sample using a swab under general anesthesia at the beginning of the endonasal surgery procedure
The shear stresss by tracking nano-batons (mPa)
The value of the shear stress by tracking nano-batons in mPa
Time frame: Day of the surgical procedure under General Anesthesia
Mucosal inflammation score (0 to 10)
Mucosal inflammation score and presence of polyps during endoscopy
Time frame: Inclusion Visit
Presence of pus at endoscopy
Presence of pus at endoscopy
Time frame: Inclusion Visit
Frequency of ciliary beat
Frequency of the ciliary beat
Time frame: Day of the surgical procedure under General Anesthesia
Shear stress by Tracking microbeads (mPa)
Value of shear stress by tracking microbeads in mPa
Time frame: Day of the surgical procedure under General Anesthesia
Presence of polyps at endoscopy
Presence of polyps at endoscopy
Time frame: Inclusion Visit
coordination of cillary beat
Cillary beat coordination evaluated by microscopy
Time frame: Day of the surgical procedure under General Anesthesia
Plan to share: No
No publications or documents are linked to this record.
This study is withdrawn, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Intercommunal Creteil