An observational study in Gastric Cancer, Atrophic Gastritis and Intestinal Metaplasia, sponsored by Chinese University of Hong Kong. Recruiting at 4 sites in 4 countries. Open to participants aged 40 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-09-07.
Sponsored by Chinese University of Hong Kong · Observational
This is a multi-center prospective case control study aiming to compare different methods of risk stratification models in predicting the risk of gastric cancer development.
The case control study would compare which type of assessment (Endoscopic / histological) is more accurate in predicting the risk of gastric cancer development.
The risk factor assessment would be based on the following criteria.
Endoscopic assessment:
2,851 studies on the registry are indexed under Stomach Neoplasms; 864 are open to participants now.
This study's planned enrollment of 400 is above the median of 274 across 670 observational studies indexed under Stomach Neoplasms.
Browse Stomach Neoplasms studies →Chinese University of Hong Kong is the lead sponsor of 1,419 studies on the registry; 487 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with or without gastric cancer undergoing elective endoscopy would be recruited if they fulfil inclusion and exclusion criteria. Subsequently they would be analysed based on "Gastric cancer" and "Non-gastric cancer" cohorts.
Two groups of patients would be recruited in this case control study.
Inclusion criteria:
Exclusion criteria:
Cohort of patients with gastric cancer
Diagnostic Test: Gastroscopy and gastric biopsies
Cohort of patients without gastric cancer
Diagnostic Test: Gastroscopy and gastric biopsies
Gastroscopy would be performed to assess the degree of atrophic gastritis and intestinal metaplasia. In addition, four random biopsies would be taken in the stomach for histological assessment of AG and IM
Endoscopic grading of atrophic gastritis (Kimura Takemoto Classification)
Endoscopic description of severity of gastric atrophy
Time frame: Cross sectional study, day 0
Endoscopic grading of intestinal metaplasia (EGGIM)
Endoscopic mapping of degree of intestinal metaplasia
Time frame: Cross sectional study, day 0
Kyoto classification of gastritis
Descriptive findings of gastritis
Time frame: Cross sectional study, day 0
Operative links on gastritis assessment (OLGA)
Biopsy based risk stratification panel based on severity of atrophic gastritis
Time frame: Cross sectional study, day 0
Operative links on gastric intestinal metaplasia (OLGIM)
Biopsy based risk stratification panel based on severity of intestinal metaplasia
Time frame: Cross sectional study, day 0
Plan to share: No
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Chinese University of Hong Kong