An observational study in Chronic Disease and Infectious Disorder, sponsored by City of Hope Medical Center. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-11-10.
Sponsored by City of Hope Medical Center · Observational
This trial collects and analyzes sweat and saliva samples compared to blood in detecting chemical concentrations in the body in patients with chronic or infectious diseases receiving medications. Wearable sweat sensors are capable of monitoring electrolytes and metabolites (sodium, potassium, glucose, lactate, etc.) for health monitoring and disease diagnosis. Designing wearable sweat sensors capable of providing information regarding drug administration may be challenging due to ultralow concentrations in biofluids. This trial seeks to determine if the use of a smart wristband can accurately measure the levels of chemicals and substances in sweat.
PRIMARY OBJECTIVE:
I. To compare novel, home-based methods of quantitating medication concentrations in either saliva or sweat to the 'gold standard' of liquid chromatography - mass spectrometry of plasma.
SECONDARY OBJECTIVES:
I. To compare novel home-based methods of quantitating substances in either saliva or sweat to the 'gold standard' in plasma.
II. Assess the ease of obtaining home-based samples.
OUTLINE:
Patients undergo collection of sweat samples via Macroduct Sweat Collection System 3710S and saliva and blood samples within 24 hours after medication administrations. Patients also complete questionnaires over 5-10 minutes and have medical charts reviewed.
After completion of study, patients are followed up periodically.
990 studies on the registry are indexed under Chronic Disease; 178 are open to participants now.
This study's planned enrollment of 100 is below the median of 419 across 249 observational studies indexed under Chronic Disease.
Browse Chronic Disease studies →City of Hope Medical Center is the lead sponsor of 670 studies on the registry; 181 are open to participants now.
Of its 30 completed or terminated interventional studies of FDA-regulated products, 12 (40%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients with chronic or infectious diseases scheduled to receive medications
Willingness to:
Exclusion Criteria:
Patients undergo collection of sweat samples via Macroduct Sweat Collection System 3710S and saliva and blood samples within 24 hours after medication administrations. Patients also complete questionnaires over 5-10 minutes and have medical charts reviewed.
Procedure: Biospecimen Collection · Other: Medical Chart Review · Other: Questionnaire Administration
Undergo collection of sweat, saliva, and blood samples
Review of medical chart
Also known as: Chart Review
Complete questionnaire
Predictive performance of the home-based sampling
Will be assessed by Pearson correlation and quantification of the predictive performance. The predictive performance of the home-based sampling methods will be assessed by calculating the median percentage prediction error (MPPE).
Time frame: Up to 4 hours
Observed plasma concentrations
Will be assessed by Pearson correlation and quantification of the predictive performance. The values from plasma will be considered the observed concentration.
Time frame: Up to 4 hours
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
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City of Hope Medical Center