An observational study in Bronchiectasis, sponsored by Bezmialem Vakif University. Completed at 1 site in Turkey. Open to participants aged 6 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-01-31.
Sponsored by Bezmialem Vakif University · Observational
Children with bronchiectasis and age-matched healthy controls will be evaluated with sit-to-stand test and six-minute walk test and utilization of STST in determining functional capacity will be investigated.
Bronchiectasis (BE) is a chronic condition which is characterized by the permanent abnormal widening of the bronchi as a result of repetitive airway infections and inflammation. Disabling cough and shortness of breath, excess mucus production, progressive airway obstruction and loss of skeletal muscle mass are the primary factors that impairs exercise tolerance in BE patients. Imaging modalities and pulmonary function test are insufficient to determine disease burden or the prognosis thus it is stated that exercise tolerance and quality of life should also be evaluated in these patients.
Exercise tolerance can be evaluated using cardiopulmonary exercise test by directly measuring oxygen consumption but the field tests such as six-minute walk test (6MWT), shuttle walk test or stair climbing tests also provides reliable data on exercise tolerance by measuring functional capacity. Among field tests, 6MWT is the most commonly used test for evaluating functional capacity in cardiopulmonary patients. Although 6MWT is easy to apply and does not require any special equipment, it still requires a 30-m long corridor and a total testing time of approx. 20 minutes considering the pre- and post-test resting periods which may impair its feasibility in some clinical settings.
Sit-to-stand test (STST) is firstly developed for older population to measure mobility related function and physical performance. Today, it is widely used in various populations including cardiopulmonary diseases such as cystic fibrosis, chronic obstructive pulmonary disease and heart failure. The investigator's aim in this study is to investigate whether STST is utilizable for evaluating functional capacity in children with BE.
368 studies on the registry are indexed under Bronchiectasis; 104 are open to participants now.
This study's enrollment of 80 is below the median of 160 across 132 observational studies indexed under Bronchiectasis.
Browse Bronchiectasis studies →Bezmialem Vakif University is the lead sponsor of 345 studies on the registry; 58 are open to participants now.
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Children diagnosed with non-cystic fibrosis bronchiectasis and age matched healthy volunteers who do not have any diagnosed chronic diseases
Exclusion Criteria:
Children with bronchiectasis
Other: Measurement of functional capacity
Age-matched healthy volunteers
Other: Measurement of functional capacity
Functional capacity of participants will be measured with six-minute walk test and sit-to-stand test
Six-minute walk test distance
Distance walked in six minutes will be recorded. Test will be conducted according to the guideline of American Thoracic Society (ATS).
Time frame: 15 minutes
Number of repetitions in sit-to-stand test
Participants will be asked to perform sit-to-stand maneuver as fast as possible for 30 seconds and the number of completed repetitions will be recorded.
Time frame: 1 Minute
Forced Vital Capacity (FVC)
FVC will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS)
Time frame: 5 minutes
Forced Expiratory Volume in 1 second (FEV1)
FEV1 will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS)
Time frame: 5 minutes
Peak Expiratory Flow (PEF)
PEF will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS)
Time frame: 5 minutes
M. Quadriceps strength
Isometric M. Quadriceps strength will be measured using electronic hand held dynamometer in sitting position.
Time frame: 3 minutes
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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Bezmialem Vakif University