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CompletedNCT04127240Updated Oct 15, 2019

The Effect of the DASH Diet Containing Meat on Muscle and Metabolic Health in Older Adults

An interventional study of DASH diet containing daily intakes of red meat in Obesity, Sarcopenia and Aging, sponsored by South Dakota State University. Completed at 1 site in United States. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-10-15.

Sponsored by South Dakota State University · Not applicable, Interventional, and Other

From the registry’s dates

  • Registered 2 years 3 months after the study started (first participant enrolled Jun 2017, registered Oct 2019).
Phase
Not applicable
Study type
Interventional
Enrollment
46
Allocation
Randomized
Ages
65 Years and older
Sex
All
01

Study summary

Age-related changes in body composition, muscular fitness, and metabolic health resulting in the onset of obesity, sarcopenia, and chronic diseases are profound public health issues that are in need of immediate attention. Effective and feasible methods, such as dietary therapies, are needed to improve health in older adults that in turn lead to independence, enhanced quality of life and reduced hospitalizations. Diet quality and dietary protein intake are vital for maintaining body composition, muscle mass and improved physical performance. Malnutrition in dietary protein intake is a major cause of reduced muscle mass, strength, and function in older adults. The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is a high-quality therapeutic diet known to improve health status in various diverse and at-risk populations resulting in improved heart health, maintained cognitive function and reductions in metabolic diseases such as diabetes, metabolic syndrome, and nonalcoholic fatty liver disease. The primary protein recommendations of the DASH diet are poultry and fish and it is recommended to decrease or exclude red meats from the diet. However, studies have demonstrated that lean red meat incorporated into a DASH-like diet doesn't exacerbate cardiovascular health indices in adults, indicating that lean red meat can be included in the DASH diet without negative effects on heart health. Although studies have reported on the DASH diet in older adults, no studies have investigated the effect of the DASH diet containing lean red meat on measures of body composition, muscle mass or metabolic health under controlled-feeding conditions. The purpose of this study was to determine the effect of the DASH diet containing daily intakes of lean red meat on indicators of body composition, muscular fitness and biomarkers of metabolic health in adults 65 and older using controlled-feeding and systems biology approaches.

02

Conditions studied

  • Obesity
  • Sarcopenia
  • Aging

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03

In context

Sarcopenia

1,208 studies on the registry are indexed under Sarcopenia; 402 are open to participants now.

This study's enrollment of 46 is below the median of 60 across 775 interventional studies indexed under Sarcopenia.

Browse Sarcopenia studies →

Lead sponsor

South Dakota State University is the lead sponsor of 16 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • 65 and older
  • Upward mobile ability

Exclusion criteria

Exclusion Criteria:

  • Under the age of 65
  • Immobility
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
46 participants (actual)

Study arms

  • Experimental
    Meat assignment in DASH intervention

    Participants consumed 3 ounces of red meat per day as a part of the DASH diet.

    Other: DASH diet containing daily intakes of red meat

  • Experimental
    Meat allocation in DASH intervention

    Participants consumed 6 ounces of red meat per day as a part of the DASH diet.

    Other: DASH diet containing daily intakes of red meat

Interventions

  • OtherDASH diet containing daily intakes of red meat

    Each participant was randomized to consume 3 or 6 ounces of red meat as a part of the DASH dietary pattern for 12-weeks.

06

What researchers measure

Primary outcomes

  1. Body weight

    Measured by bioelectrical impedance

    Time frame: Change in body weight from baseline to 3 months

  2. Hand grip strength

    Measured by a hand-held dynamometer

    Time frame: Change in strength from baseline to 3 months

  3. Glucose

    Measure serum glucose using colorimetry assay

    Time frame: Change in glucose concentrations from baseline to 3 months

07

Study locations

1 site
  • South Dakota State University
    Brookings, South Dakota 57006, United States
08

References and documents

Publications

  • Perry CA, Van Guilder GP, Butterick TA. Decreased myostatin in response to a controlled DASH diet is associated with improved body composition and cardiometabolic biomarkers in older adults: results from a controlled-feeding diet intervention study. BMC Nutr. 2022 Mar 15;8(1):24. doi: 10.1186/s40795-022-00516-9. PubMed 35287731 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 15, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04127240
Lead sponsor
South Dakota State University
Responsible party
Cydne Perry (Assistant Professor, South Dakota State University) — Principal investigator
First posted
Oct 15, 2019
Start date
Jun 15, 2017
Primary completion
Nov 10, 2018
Completion
Nov 10, 2018
Last update
Oct 15, 2019

Study contacts

Cydne A Perry, PhD
principal investigator · South Dakota State University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2019. You cannot join it, but the record below documents what was studied.

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