An observational study in Legionnaires' Disease, sponsored by Dr Philippe CLEVENBERGH. Completed at 3 sites in Belgium. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-07-20.
Sponsored by Dr Philippe CLEVENBERGH · Observational
Legionnaire's disease (LD) is a major cause of both community acquired and nosocomial pneumonia, with Legionella pneumophila serogroup A (Lp1) being the most virulent and the greatest cause of disease. Sample culture of low respiratory tract is considered the gold standard in the diagnosis of LD, however its sensitivity seems to be poor and its performance is technically demanding. The introduction of urinary antigen detection testing (LUA) brought a major advance in LD diagnosis, with upt to 95% of cases in Europe being diagnosed with this method. Despite the high sensitivity of LUA for Lp1, ranging from 80-90%, its negative predictive value is low in other serogroup than Lp1 and therefore, Legionella may be unrecognized as agent of pneumonia. Although underdiagnosed and underreported, LD represents the second most common cause of pneumonia requiring admission in intensive care unit (ICU). Average fatality rate of LD in Europe reaches 10%, but its mortality is considered to be even higher in nosocomial patients.
Despite the higher fatality rate in hospitalized LD patients, poor is the knowledge on the risk factors that could induce disease and that increase mortality in the hospitalized population affected by LD. In order to shed more light on this topic a cohort of patients diagnosed with LD in the last 3 years will be retrospectively examined.
This is the only study on the registry with Dr Philippe CLEVENBERGH as lead sponsor.
Counted across the registry records on this site, refreshed daily.
All confirmed human cases of Legionnaires' disease diagnosed within the CHU Brugmann hospital, the St Pierre Hospital and the UZ Brussel Hospital. The definition of Legionnaires' disease diagnosis is met whether a seroconversion is detected or positive respiratory samples cultures are objectivized or positive LUA are observed. Seroconversion is defined as a rising of Legionella antibodies, dilution superior to 1/128 by indirect immunofluorescence. Nosocomial cases of Legionnaires' disease are defined in this study as the ones having an onset of symptoms more than 10 days after hospitalization.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
All confirmed human cases of Legionnaires' disease diagnosed within the CHU Brugmann hospital within the last 3 years, from 01/01/2016 till 31/12/2018. A similar approach will be followed for the St Pierre and the UZ Brussel Hospitals.
Exclusion Criteria:
Pregnant women.
All confirmed human cases of Legionnaires' disease diagnosed within the CHU Brugmann hospital within the last 3 years: from 01/01/2016 till 31/12/2018. A similar approach will be followed for the St Pierre Hospital and the UZ Brussel Hospital.
Other: Data extraction from medical files
Data extraction from medical files
All cause mortality
All cause mortality
Time frame: 3 years
Severity respiratory failure
Arterial pression of oxygen inferior to 600mmHg at diagnosis
Time frame: 3 years
Age
Age at diagnosis
Time frame: One day
Sex
Sex
Time frame: One day
Charlson comorbidity index
This is a health tool that assesses the comorbidity risk associated to a series of conditions in order to offer medical specialists an informed decision making process in terms of specific screenings or medical procedures.The index accounts for the patient age and 16 different conditions, and ranges from 0 till 37.
Time frame: One day
Smoking status
Smoking (yes/no) at diagnosis
Time frame: One day
Nosocomial disease (yes/no)
Nosocomial cases of Legionnaires' disease are defined in this study as having an onset of symptoms more than 10 days after hospitalization.
Time frame: One day
C reactive protein
C reactive protein level at diagnosis
Time frame: One day
White blood cells
White blood cells level at diagnosis
Time frame: One day
Creatinine
Creatinine level at diagnosis
Time frame: One day
Urea
Urea level at diagnosis
Time frame: One day
Chest X Ray
Descriptive analysis of Chest X Ray findings at diagnosis
Time frame: One day
Method of diagnosis
Name of the method of diagnosis (urinary antigen, seroconversion, cultures).
Time frame: One day
Intensive care unit hospitalization
Intensive care unit hospitalization (yes/no)
Time frame: One day
Antibiotics
Name of antibiotics given
Time frame: One day
Antibiotic treatment duration
Antibiotic treatment duration
Time frame: up to 40 days
Plan to share: No
No publications or documents are linked to this record.
Ran from Aug 2019 to primary completion in Sep 2019, 1 month.
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This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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Legionnaires' Disease