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CompletedNCT04104308Updated Mar 15, 2024

Association of Egg and Dietary Cholesterol Consumption With Mortality and Diseases

An observational study in Mets and Death, sponsored by Zhejiang University. Completed. Per ClinicalTrials.gov, last updated 2024-03-15.

Sponsored by Zhejiang University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
33,453
Sex
All
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Study summary

To assess the associations between egg and dietary cholesterol consumption with mortality and metabolic syndrome (MetS).

Read the detailed description

Substitution models, sensitivity analyses, subgroup analyses and multiple linear regression analyses will be conducted to specifically estimate the hazard ratios and 95% confidence intervals of mortality and MetS associated with egg and cholesterol consumption.

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Conditions studied

  • Mets
  • Death
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In context

Lead sponsor

Zhejiang University is the lead sponsor of 351 studies on the registry; 165 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Sampling method
Probability sample

Study population

The CHNS is a nationwide cohort survey in China, which was established as a joint project of the University of North Carolina at Chapel and the China Center for Disease Control and Prevention (CCDC).This national-wide survey adopted a novel measure from multiple dimensions, which helped to understand how the long-term social and economic changes affected nutrition and health-related outcomes of Chinese. Until now, 10 rounds of survey (1989, 1991, 1993, 1997, 2000, 2004, 2006, 2009, 2011 and 2015) have been conducted.

Inclusion criteria

  • participants aged ≥20 y

Exclusion criteria

Exclusion Criteria:

  • missing creatinine, age, cannot be linked to socio-demographic data; aged less than 20; without complete dietary data .
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
33,453 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna
06

What researchers measure

Primary outcomes

  1. mortality

    mortality

    Time frame: participants were followed up from 1991 to 2015

Secondary outcomes

  1. metabolic syndrome

    MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III (NCEP: ATP III) criteria for Asian-Americans.

    Time frame: The blood samples were collected in 2009 for the first time.

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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Wu F, Zhuang P, Zhan C, Shen X, Jiao J, Zhang Y. Egg and Dietary Cholesterol Consumption and the Prevalence of Metabolic Syndrome: Findings from a Population-Based Nationwide Cohort. J Acad Nutr Diet. 2022 Apr;122(4):758-770.e5. doi: 10.1016/j.jand.2021.09.010. Epub 2021 Oct 11. PubMed 34506988 ↗
  • Zhuang P, Jiao J, Wu F, Mao L, Zhang Y. Egg and egg-sourced cholesterol consumption in relation to mortality: Findings from population-based nationwide cohort. Clin Nutr. 2020 Nov;39(11):3520-3527. doi: 10.1016/j.clnu.2020.03.019. Epub 2020 Mar 28. PubMed 32307193 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 15, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04104308
Lead sponsor
Zhejiang University
Responsible party
Jingjing Jiao (Associate Professor, Zhejiang University) — Principal investigator
First posted
Sep 26, 2019
Start date
Jan 1, 1991
Primary completion
Jan 1, 2015
Completion
Dec 31, 2015
Last update
Mar 15, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2024. You cannot join it, but the record below documents what was studied.

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