An observational study in Allogeneic Hematopoietic Stem Cell Recipients, Acute Respiratory Infection and Parainfluenza Virus (PIV), sponsored by Assistance Publique - Hôpitaux de Paris. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-07-17.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
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Bronchiolitis obliterans (BO) is the well-known manifestation of the chronic pulmonary graft-versus-host disease(GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The pathophysiology of BO is, however, poorly known. The available data strongly support the role of respiratory viruses, in particular paramyxoviruses (parainfluenzae virus (PIV), respiratory syncytial virus, metapneumovirus). It is likely that the alloimmune response triggered by the respiratory virus is inadequate and leads to the peribronchiolar fibrotic process. The objective is to analyze the kinetics of profiles of the blood and respiratory host responses resulting from a high or low parainfluenza respiratory infection, in order to evaluate if the occurrence of a BO is associated with a specific signature We will evaluate the predictive signature of a BO after a parainfluenza virus infection by characterizing the differences between the patients evolving and those not evolving to a BO at 2 months after the infection.
31 studies on the registry are indexed under Paramyxoviridae Infections; 3 are open to participants now.
Browse Paramyxoviridae Infections studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,596 studies on the registry; 1,037 are open to participants now.
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Adult recipients of allogeneic HSCT with PIV pulmonary infection
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Exclusion Criteria:
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Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
eligible patients with 10% decline in Forced Expiratory Volume (FEV1) at 2 months
Other: samples
eligible patients free of 10% FEV1 decline at 2 months
Other: samples
blood sample nasal swab
Host response in both blood and respiratory tract after PIV infection
Time frame: Up to 6 months
Identify the cellular signaling pathways associated with the development of BO following parainfluenzae virus infection
Time frame: Up to 6 months
Evaluate differences in transcriptomic profiles between blood and respiratory tract
Time frame: Up to 6 months
Plan to share: Undecided
No publications or documents are linked to this record.
Started Mar 2021 (actual). Primary completion is estimated for Mar 2025, 48 months after the start.
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