An interventional study of Meal in Iron-deficiency and Iron Deficiency Anemia, sponsored by Florida State University. Completed at 1 site in United States. Per ClinicalTrials.gov, last updated 2020-02-27.
Sponsored by Florida State University · Not applicable, Interventional, and Basic science
Iron is a nutritionally essential mineral required for optimal physical and cognitive performance. Endurance exercise often leads to declines in iron status; however, the reason for the decline is not known. The primary objective of the proposed study is to determine the effects of an acute bout of strenuous endurance exercise on iron absorption and status and markers of inflammation in human volunteers. The investigators hypothesize that an acute bout of strenuous endurance exercise, compared to rest, will reduce iron absorption, resulting in diminished iron status, and that reduced iron absorption will be negatively associated with markers of inflammation. A secondary objective is to monitor iron status throughout a season of competition.
644 studies on the registry are indexed under Anemia, Iron-Deficiency; 105 are open to participants now.
This study's enrollment of 31 is below the median of 100 across 503 interventional studies indexed under Anemia, Iron-Deficiency.
Browse Anemia, Iron-Deficiency studies →Florida State University is the lead sponsor of 241 studies on the registry; 46 are open to participants now.
Of its 15 completed or terminated interventional studies of FDA-regulated products, 9 (60%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
During the exercise arm, volunteers will complete a planned workout, as prescribed by the coach. The workout will be designed to be strenuous and induce an inflammatory response.
Other: Meal
The rest arm will be coordinated with a planned non-workout day, as prescribed by the coach, where volunteers are either scheduled to not run or go for an easy recovery run (\<6 miles at a self-described "easy" pace) later in the afternoon.
Other: Meal
Participants will consume a meal containing a stable iron isotope following exercise or rest.
Change in fractional iron absorption
Stable iron isotopes
Time frame: Red blood cells collected on day 0 and day 14
Change in concentration of ferritin in ng/mL
Blood measure
Time frame: Day 0 and day 14
Change in concentration of soluble transferrin receptor in nmol/L
Blood measure
Time frame: Day 0 and day 14
Change in concentration of hemoglobin in g/L
Blood measure
Time frame: Day 0 and day 14
Change in concentration of hematocrit as %
Blood measure
Time frame: Day 0 and day 14
Change in concentration of hepcidin in ng/mL
Blood measure
Time frame: Day 0 and day 14
Change in concentration of IL-6 in pg/mL
Blood measure
Time frame: Day 0 and day 14
Plan to share: No
This study is completed, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.
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Florida State University