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TerminatedNCT04069741Updated May 5, 2022

Treating Depression in Patients With De Quervain's Tenosynovitis; An Integrated Web Based Skills Intervention

An interventional study of Decision Aid and Toolkit for de Quervain's in De Quervain Disease, sponsored by Massachusetts General Hospital. Terminated at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-05-05.

Sponsored by Massachusetts General Hospital · Not applicable, Interventional, and Treatment

Why this study was terminated
Data difficult to collect due to the COVID-19 pandemic.
Phase
Not applicable
Study type
Interventional
Enrollment
22
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

This study evaluates a Decision Aid to help patients with de Quervain's tenosynovitis decide how to treat their condition.

For patients with symptoms of depression, half the participants will receive a psychological intervention (Toolkit) to improve depression and pain from de Quervain's tenosynovitis.

The investigators hypothesize that both the Decision Aid and the Toolkit will be feasible, and that the Toolkit will improve pain and function compared to usual care.

Read the detailed description

The investigators are doing this research to see if they can improve the management of patients with de Quervain's tendinopathy. In the first part of this study, a Decision Aid (DA) has been developed to help participants make choices about their treatment.

Decision aids are designed to provide patients with balanced, complete, and understandable information about their options for management of their condition, as well as risks and benefits, in order to help them determine their preferences according to their values. Research has shown that patients felt more knowledgeable and better informed with a more active role in decision making after using DAs.

Additionally, research has shown that depression affects pain and disability experienced by patients with de Quervain's tenosynovitis. In the second part of our study, the investigators want to see whether a web based skills intervention (Toolkit) is more effective than usual medical care in improving pain and disability in patients with de Quervain's tenosynovitis and symptoms of depression.

The Toolkit is delivered online and can be accessed at home. Similar skills interventions in patients with musculoskeletal injury have been shown to improve pain and function.

02

Conditions studied

  • De Quervain Disease
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Adults (≥18 years) diagnosed with de Quervain's tenosynovitis
  • English fluency and literacy
  • Ability to give informed consent

Exclusion criteria

Exclusion Criteria:

  • Inability or unwillingness to participate in decision aid (DA) and/or Toolkit-depression
  • Major medical comorbidity expected to worsen in the next 6 months
  • Comorbid chronic pain condition
  • Antidepressant medications changes in the past 6 months
  • Severe and untreated mental health conditions or active substance dependence
  • Secondary gains such as litigations or worker compensation procedures that may interfere with patients' motivation for treatment
  • No online device available to use the DA and Toolkit-depression
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
22 participants (actual)

Study arms

  • Other
    Usual care, no depression

    Participants without symptoms of depression who have the opportunity to use a Decision Aid but otherwise receive Usual care

    Other: Decision Aid

  • Other
    Usual care, depression

    Participants with symptoms of depression who are randomized to receive Usual care (in addition to the Decision Aid)

    Other: Decision Aid

  • Active comparator
    Toolkit, depression

    Participants with symptoms of depression who are randomized to receive the Toolkit intervention in addition to Usual care

    Other: Decision Aid · Behavioral: Toolkit for de Quervain's

Interventions

  • OtherDecision Aid

    A website that contains information about de Quervain's tenosynovitis and the options for treatment

  • BehavioralToolkit for de Quervain's

    A website that offers 4 sessions of mind-body skills to help manage pain from de Quervain's tenosynovitis

05

What researchers measure

Primary outcomes

  1. QuickDASH score (Disabilities of the Arm Shoulder and Hand)

    This questionnaire measures individual's ability to complete daily tasks and the severity of their symptoms. The scoring scale ranges from 0 (no disability) to 100 (most severe disability).

    Time frame: 6 months

  2. Numerical Pain Rating Scale

    This scale measures the patient's pain intensity. The scale ranges from 0 (no pain) to 10 (worst possible pain).

    Time frame: 6 months

Secondary outcomes

  1. Patient Health Questionnaire 9

    This questionnaire is used for screening and measuring the severity of depression. The scale ranges from 0 to 27 overall. A score between the range of 5-9 indicates minimal symptoms of depression. A score between 10-14 suggests minimal depression or mild, major depression. A range of 15-19 indicates moderately severe, major depression, and a score of greater than 20 suggests severe, major depression.

    Time frame: 6 months

  2. Pain Catastrophizing Scale

    This scale measures the individual's level of catastrophic thinking related to pain. They are asked about the thoughts and feelings they have when experiencing pain. The responses range from 0 (not at all) to 4 (all the time). The total score ranges from O-52. There are three subscale scores that assess rumination, magnification, and helplessness. The helplessness score ranges from 0 (not helpless) to 24 (severe helplessness). The rumination score ranges from 0 (don't think about the pain) to 16 (constantly think about how much it hurts). The magnification score ranges from 0 (does not feel like the pain is or will be more serious) to 12 (thinks the pain will get more serious).

    Time frame: 6 months

06

Study locations

1 site
  • Hand and Arm Center, Massachusetts General Hospital
    Boston, Massachusetts 02114, United States
07

References and documents

Study documents

  • Protocol and statistical analysis plan · Jan 17, 2019

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT04069741
Lead sponsor
Massachusetts General Hospital
Responsible party
Neal Chung-Jen Chen (Interim Chief of the Hand & Arm Center, Massachusetts General Hospital) — Principal investigator
First posted
Aug 28, 2019
Start date
Dec 10, 2018
Primary completion
Feb 19, 2022
Completion
Feb 19, 2022
Last update
May 5, 2022

Study contacts

Neal C Chen, MD
principal investigator · Hand and Arm Center Lead, Massachusetts General Hospital
Ana-Maria Vranceanu, PhD
principal investigator · IBHCRP, Massachusetts General Hospital

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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