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CompletedNCT04027868GREATUpdated Jun 8, 2026

Genomic BRCA and Extensive ovArian Cancer Testing

An observational study in Epithelial Ovarian Cancer, Peritoneal Cancer and Fallopian Tube Cancer, sponsored by ARCAGY/ GINECO GROUP. Completed at 137 sites in France. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-08.

Sponsored by ARCAGY/ GINECO GROUP · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,500
Ages
18 Years and older
Sex
Female
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Study summary

This is a prospective observational French multicenter cohort in patients with ovarian and/or primitive peritoneal and/or fallopian tubes carcinoma, histologically confirmed, with an advanced stage at diagnosis (stage III to IV FIGO 2014). The objective is to constitute a clinico-biological database that allows to correlate clinical and progressive features of ovarian cancer patients based on tumor genomics and molecular detected abnormalities.

Read the detailed description

This is a prospective observational French multicenter cohort in patients with ovarian and/or primitive peritoneal and/or fallopian tubes carcinoma, histologically confirmed, with an advanced stage at diagnosis (stage III to IV FIGO 2014). The objective is to constitute a clinico-biological database that allows to correlate clinical and progressive features of ovarian cancer patients based on tumor genomics and molecular detected abnormalities.

02

Conditions studied

  • Epithelial Ovarian Cancer
  • Peritoneal Cancer
  • Fallopian Tube Cancer
03

In context

Carcinoma, Ovarian Epithelial

1,617 studies on the registry are indexed under Carcinoma, Ovarian Epithelial; 246 are open to participants now.

This study's enrollment of 1,500 is above the median of 150 across 304 observational studies indexed under Carcinoma, Ovarian Epithelial.

Browse Carcinoma, Ovarian Epithelial studies →

Lead sponsor

ARCAGY/ GINECO GROUP is the lead sponsor of 51 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with ovarian and/or primitive peritoneal and/or fallopian tubes carcinoma, histologically confirmed, with an advanced stage at diagnosis (stage III to IV FIGO 2014)

Inclusion criteria

  • Patient older than 18 years.
  • Patient with ovarian and/or primitive peritoneal and/or fallopian tubes carcinoma, histologically confirmed, with an advanced stage at diagnosis (stage III to IV FIGO 2014)
  • Patient in first line therapy
  • Available tumor sample fixed in formalin and included in paraffin (FFPE):

    • in pre-chemotherapy, insofar as possible
    • having a sufficient tumor surface, with a final cellularity of at least 20%
  • Identification of a molecular genetics' cancer platform participant in GREAT and an onco-geneticists team working with the investigator team
  • Patient consenting her data to be collected and submitted through an automated processing
  • Patient beneficiary from the French social security

Exclusion criteria

Exclusion Criteria:

  • Patient with a mucinous ovarian carcinoma
  • Patient pregnant or breastfeeding
  • Patient under legal protection (guardianship or court order) or unable to consent
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,500 participants (actual)
Target follow-up
10 Years
Patient registry
Yes
Biospecimen retention
Samples with dna
06

What researchers measure

Primary outcomes

  1. Correlation between Progression Free Survival (PFS) and the detected tumor genetic abnormalities

    Time frame: From baseline until the date of progression or death, which ever occurs earlier, assessed up to 10 years

Secondary outcomes

  1. Correlation between age and the detected tumor genetic abnormalities

    Time frame: Baseline

  2. Correlation between histology status and the detected tumor genetic abnormalities

    Time frame: Baseline

  3. Correlation between FIGO stage and the detected tumor genetic abnormalities

    Time frame: Baseline

  4. Correlation between surgery resection status and the detected tumor genetic abnormalities

    Time frame: Up to 10 years

  5. Correlation between treatment response and the detected tumor genetic abnormalities

    Time frame: Up to 10 years

  6. Correlation between Overall survival (OS) and the detected tumor genetic abnormalities

    Time frame: From baseline to death, assessed up to 10 years

Other outcomes

  1. Percentage of patients with both germinal and tumoral BRCA tests

    Time frame: Up to 10 years

  2. Percentage of patients with a first germinal BRCA test, a first tumoral BRCA test, or simultaneous germinal and tumoral tests

    Time frame: Up to 10 years

  3. Percentage of patients with and exploitable tumoral block for exploratory transversal researches

    Time frame: Up to 10 years

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Study locations

137 sites
  • Centre de Radiothérapie et d'Oncologie de Moyenne Garonne (CROMG)
    Agen, 47000, France
  • Hôpital Privé d'Aix en Provence
    Aix-en-Provence, 13080, France
  • Centre Hospitalier Général d'Aix-en-Provence
    Aix-en-Provence, France
  • CHU Amiens
    Amiens, France
  • Clinique Victor PAUCHET
    Amiens, France
  • Institut de Cancérologie de l'Ouest - ICO
    Angers, France
  • Hôpital Privé d'Antony - Ramsay Santé
    Antony, 92160, France
  • CH Arras
    Arras, France
  • CH Auxerre
    Auxerre, France
  • Institut Sainte Catherine
    Avignon, France
  • Clinique Belharra
    Bayonne, 64100, France
  • CH Côte Basque
    Bayonne, France
  • Centre Hospitalier de Beauvais
    Beauvais, 60021, France
  • CHRU Jean Minjoz
    Besançon, France
  • Reims Icone
    Bezannes, 51100, France
  • CH de Blois
    Blois, France
  • Hôpital Avicenne
    Bobigny, 93009, France
  • CHU de Bordeaux - Hôpital Pellegrin
    Bordeaux, France
  • Clinique Tivoli
    Bordeaux, France
  • Institut Bergonié
    Bordeaux, France
  • Polyclinique Bordeaux Nord
    Bordeaux, France
  • Centre Hospitalier Fleyriat - BOURG-EN-BRESSE
    Bourg-en-Bresse, France
  • CHU Brest
    Brest, France
  • Hôpital Femme Mère Enfant
    Bron, 89500, France
  • Centre François Baclesse
    Caen, France
  • Centre Maurice Tubiana
    Caen, France
  • CH de Cahors
    Cahors, France
  • CH Carcassonne
    Carcassonne, France
  • Hôpital Général de Castres
    Castres, France
  • Medipole de Savoie
    Challes-les-Eaux, France
  • CH Chalon sur Saone
    Chalon-sur-Saône, France
  • CH Metropole Savoie
    Chambéry, France
  • Centre d'Oncologie et de Radiothérapie 37
    Chambray-lès-Tours, France
  • Centre Hospitalier de Chateauroux
    Châteauroux, 36000, France
  • CHPC - Hôpital Louis Pasteur
    Cherbourg, France
  • CH Cholet
    Cholet, France
  • Hôpital Antoine Béclère
    Clamart, France
  • Centre Jean Perrin
    Clermont-Ferrand, France
  • CH Alpes Léman
    Contamine-sur-Arve, France
  • Centre Hospitalier Sud Francilien (Site Gilles de Corbeil)
    Corbeil-Essonnes, 91106, France
  • Clinique des Cèdres
    Cornebarrieu, 31700, France
  • Clinique de Flandre
    Coudekerque-Branche, France
  • Groupe Hospitalier public du Sud de l'Oise (GHPSO)
    Creil, France
  • CHI Creteil
    Créteil, France
  • Centre Georges François Leclerc
    Dijon, France
  • CHU Dijon
    Dijon, France
  • Institut de Cancérologie de Bourgogne - GRReCC
    Dijon, France
  • Clinique du Mousseau (CMCO) - Ramsay Santé
    Évry, 91000, France
  • Centre Hospitalier Intercommunal de Fréjus Saint Raphael
    Fréjus, 83600, France
  • GH Mutualiste de Grenoble
    Grenoble, France
  • Hôpital Privé Drôme Ardèche - Clinique Pasteur
    Guilherand-Granges, 07500, France
  • Centre Hospitalier Marne-la-Vallée
    Jossigny, France
  • Centre Hospitalier Départemental de Vendée
    La Roche-sur-Yon, 85925, France
  • CHU Grenoble Alpes - Site Nord (La Tronche)
    La Tronche, France
  • Hôpital André Mignot
    Le Chesnay, France
  • Les Hôpitaux de Chartres
    Le Coudray, France
  • Hôpital Privé de l'Estuaire
    Le Havre, 76600, France
  • CHU Bicêtre
    Le Kremlin-Bicêtre, France
  • Centre Hospitalier du Mans
    Le Mans, France
  • CH de Lens
    Lens, France
  • Institut Hospitalier Franco-Britannique
    Levallois-Perret, France
  • Polyclinique de Limoges - Clinique Chenieux
    Limoges, 87039, France
  • CHU de Limoges - Hôpital Dupuytren
    Limoges, 87042, France
  • Groupe Hospitalier Bretagne Sud - Hôpital du Scorff
    Lorient, France
  • HCL - Hôpital de la Croix Rousse
    Lyon, 60004, France
  • Clinique de l'infirmerie Protestante
    Lyon, 69300, France
  • Centre Léon Bérard
    Lyon, France
  • Clinique de la Sauvegarde
    Lyon, France
  • Hôpital Privé Jean Mermoz
    Lyon, France
  • APHM - Hôpital de la Timone
    Marseille, France
  • Hôpital Nord
    Marseille, France
  • Institut Paoli Calmettes
    Marseille, France
  • Centre Hospitalier Layné
    Mont-de-Marsan, 40024, France
  • Hôpital Nord Franche Comté
    Montbéliard, France
  • CH de Montelimar
    Montélimar, France
  • Centre de Cancérologe du Grand Montpellier
    Montpellier, France
  • CHRU de Montpellier - Hôpital Saint-Eloi
    Montpellier, France
  • ICM - Val d'Aurelle
    Montpellier, France
  • Centre Azuréen de Cancérologie
    Mougins, 06250, France
  • Oracle - Centre d'Oncologie de Gentilly
    Nancy, France
  • Hôpital Privé du Confluent
    Nantes, France
  • Clinique Hartmann
    Neuilly-sur-Seine, France
  • Centre Antoine Lacassagne
    Nice, 06000, France
  • Institut de Cancérologie du Gard - ONCOGARD
    Nîmes, 30029, France
  • Institut de Cancérologie du Gard
    Nîmes, France
  • CHR Orléans
    Orléans, France
  • Hôpital de la Pitié Salpétrière
    Paris, 75000, France
  • GH Saint Joseph
    Paris, France
  • Groupe Hospitalier Diaconesses - Croix Saint-Simon
    Paris, France
  • HEGP
    Paris, France
  • Hôpital Bichat
    Paris, France
  • Hôpital Cochin
    Paris, France
  • Hôpital Lariboisière
    Paris, France
  • Institut Curie
    Paris, France
  • Institut Mutualiste Montsouris
    Paris, France
  • CH Pau
    Pau, France
  • Centre Catalan d'Oncologie
    Perpignan, France
  • CH Perpignan
    Perpignan, France
  • Clinique Francheville
    Périgueux, France
  • HCL - Centre Hospitalier Lyon Sud
    Pierre-Bénite, 69006, France

Showing the first 100 of 137 sites.

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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 8, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04027868
Lead sponsor
ARCAGY/ GINECO GROUP
Collaborators
AstraZeneca
Responsible party
Sponsor
First posted
Jul 22, 2019
Start date
Dec 6, 2019
Primary completion
Nov 7, 2022
Completion
Nov 7, 2022
Last update
Jun 8, 2026

Study contacts

Thibault De La Motte Rouge, MD.
principal investigator · Centre Eugène Marquis, Rennes

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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