An interventional study of Oral glucose tolerance test (OGTT) with or without metformin in Impaired Glucose Tolerance and Type2 Diabetes, sponsored by University Hospital, Lille. Completed. Open to female participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-04-22.
Sponsored by University Hospital, Lille · Not applicable, Interventional, and Treatment
Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.
It is usually recommended to take metformin during the meal to decrease gastrointestinal side effects. However, if metformin decreases carbohydrate absorption, this might not be the most efficient intake.
To study the influence of preprandial metformin administration on carbohydrate absorption, it will repeat 3 oral glucose tolerance test on obese dysglycemic patients, without metformin or with metformin administer 30 or 60 minutes before. We will also evaluate how it impacts gastrointestinal tolerance.
778 studies on the registry are indexed under Glucose Intolerance; 129 are open to participants now.
This study's enrollment of 1 is below the median of 60 across 645 interventional studies indexed under Glucose Intolerance.
Browse Glucose Intolerance studies →University Hospital, Lille is the lead sponsor of 625 studies on the registry; 141 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Other: Oral glucose tolerance test (OGTT) with or without metformin
Other: Oral glucose tolerance test (OGTT) with or without metformin
Each participant will have 3 OGTT, one without metformin, one with metformin30 minutes before the test, one with metformin 60 minutes before the test. The order for each test will be randomized.
Area under the curve of D-Xylose
Time frame: During the 3 hours OGTT
Number of Participants with gastrointestinal side effects
Time frame: During the 3 hours OGTT
Area under the curve of blood glucose
Time frame: During the 3 hours OGTT
Area under the curve of insulin
Time frame: During the 3 hours OGTT
Area under the curve of GLP-1
Time frame: During the 3 hours OGTT
No study locations are listed for this record.
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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University Hospital, Lille