An interventional study of Oral Antibiotics-Close Monitoring and Standard of Care in Prolonged Air Leak, sponsored by Mayo Clinic. Terminated at 2 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-10-07.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Prevention
This study is a multicenter, randomized trial for the treatment of subjects discharging from the hospital with a chest tube and valve in place. Subjects will be randomized to receive oral antibiotics and close monitoring, defined as twice weekly telephone calls by a member of the care team, of their chest tube and valve or standard of care, defined as no calls from the care team but waiting for the subject to contact the care team when the air leak has stopped.
This study is a multicenter, randomized trial for the treatment of subjects discharging from the hospital with a chest tube and valve in place. Subjects will be screened prior to discharging from the hospital and interested qualified subjects will be consented and offered participation in this trial. Once consent has been obtained the subject will be randomized to receive oral antibiotics and close monitoring, defined as twice weekly telephone calls by a member of the care team, of their chest tube and valve or standard of care, defined as no calls from the care team but waiting for the subject to contact the care team when the air leak has stopped. The subject will be followed until they have their chest tube removed.
Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.
Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Oral Antibiotics
Other: Oral Antibiotics-Close Monitoring
Standard of Care
Other: Standard of Care
To receive oral antibiotics and close monitoring, defined as twice weekly telephone calls by a member of the care team, of their chest tube and valve.
No calls from the care team but waiting for the subject to contact the care team when the air leak has stopped.
Change in empyema in patient's discharging with an indwelling chest tube and valve.
The proportion of patients having 30-day empyema in the two treatment arms will be estimated and reported.
Time frame: 30 days post discharge
Change of 30-day readmission in patient's discharging with an indwelling chest tube and valve.
The proportion of patients having a 30-day readmission in the two treatment arms will be estimated and reported.
Time frame: 30 days post discharge
Plan to share: No
This study is terminated, as verified in Oct 2025. You cannot join it, but the record below documents what was studied.
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