An observational study in Cardiopulmonary Bypass and Lactate, sponsored by Hualien Tzu Chi General Hospital. Completed. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2019-05-02.
Sponsored by Hualien Tzu Chi General Hospital · Observational
Tissue hypoperfusion during cardiopulmonary bypass (CPB) affects cardiac surgical outcomes. Lactate, an end product of anaerobic glycolysis from oxygen deficit, is an obtainable marker of tissue hypoxia. The investigators aimed to determine the value of blood lactate level during CPB in adult cardiac surgeries in predicting outcomes.
The investigators retrospectively reviewed the patients underwent cardiac surgeries with CPB from January 2015 to December 2015. The patient's characteristics, pre-operative status, surgical type, and intra-operative lactate levels were collected. The outcomes were in-hospital mortality and complications. Receiver operating characteristics (ROC) curves were used to assess the ability of peak lactate level during CPB to predict in-hospital mortality.
The baseline characteristics, including age, gender, body mass index (BMI), comorbidities, left ventricular ejection fraction (LVEF, %), European system for cardiac operative risk evaluation II (EuroSCORE II), pre-operative hematocrit, and serum creatinine levels were recorded. The surgical type was classified as coronary artery bypass grafting (CABG), valve surgery, combined surgery including CABG and valve surgery, great vessel surgery including aortic dissection, and other surgeries. The priority of surgery was classified as elective, urgent, and emergent. The intra-operative variables included CPB time, aortic cross-clamp time, initial lactate level at the beginning of the operation, and the peak lactate level during CPB.
Hualien Tzu Chi General Hospital is the lead sponsor of 5 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
adults patients underwent cardiac surgeries with cardiopulmonary bypass from January 2015 to December 2015
Exclusion Criteria:
check lactate levels routinely during cardiac operations with cardiopulmonary bypass, choose the peak lactate data
Diagnostic Test: serum lactate
check lactate levels during cardiopulmonary bypass in adult cardiac operations
in-hospital mortality
peak lactate level during cardiopulmonary bypass predicts in-hospital mortality
Time frame: From date of inclusion until date of death from any cause during hospitalization, assessed up to one year
No study locations are listed for this record.
Plan to share: Undecided — The individual participant data (IPD) will be available on request.
This study is completed, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.
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Hualien Tzu Chi General Hospital