An interventional study of Activity regime in Overweight and Obesity, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to female participants aged 45 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-01-20.
Sponsored by Maastricht University Medical Center · Not applicable, Interventional, and Prevention
Research has shown that replacing sitting time with low intensity physical activity (such as slowly walking and standing) has beneficial effects on metabolic health, like insulin sensitivity, comparable to improvements after sitting all day in combination with 1h streneous exercise.
The main objective of this study is to investigate the underlying mechanisms responsible for improved insulin sensitivity after 4 days of sitting less compared to sitting and exercise in healthy obese women. Our secondary objective is to investigate the effects of sitting less on cardio metabolic parameters.
3,670 studies on the registry are indexed under Overweight; 849 are open to participants now.
This study's enrollment of 12 is below the median of 73 across 3,175 interventional studies indexed under Overweight.
Browse Overweight studies →Maastricht University Medical Center is the lead sponsor of 835 studies on the registry; 122 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Subjects will follow the sit regime during four days. Each day consists of 14 hours sitting, 1 hour walking and 1 hour standing and 8 hours sleeping.
Other: Activity regime
Subjects will follow the sit less regime during four days. Each day will consist of 9 hours sitting, 3 hours walking, 4 hours standing and 8 hours sleeping.
Other: Activity regime
Subjects will follow the exercise regime during four days. Each day will consist of 13 hours sitting, 1 hour walking, 1 hour standing, 1 hour exercise and 8 hours sleeping. The cycle session will be at approximately 60% maximal power. Exact cycling intensity and duration will be calculated to ensure equal total energy expenditure between the sitting less and the exercise regime.
Other: Activity regime
Activity regime of 4 days followed by a test day.
Insulin sensitivity
2-step hyperinsulinemic euglycemic clamp
Time frame: Day 5 of intervention period
ex vivo skeletal muscle mitochondrial respiration
oxygraph
Time frame: Day 5 of intervention period
substrate oxidation
indirect calorimetry RER
Time frame: Day 5 of intervention period
Intrahepatic lipid content
magnetic resonance spectroscopy
Time frame: Day 5 of intervention period
Blood pressure
average resting blood pressure over 30 minutes
Time frame: Day 5 of intervention period
Plasma cardio metabolic markers
endothelial dysfunction score (average Z-score of log transformed plasma sVCAM1, sICAM1 and sE-selectin)
Time frame: Day 5 of intervention period
This study is completed, as verified in Jan 2021. You cannot join it, but the record below documents what was studied.
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Maastricht University Medical Center