Enhancing Operational Performance in Healthy Rested Soldiers With Pharmacological Stimulants

• Must be at least 18 years old.
• Must have normal hearing, vision or corrected to normal vision, and cognitive function as determined by self-report
• Must have obtained at minimum 6 hours of sleep prior to all testing sessions, as assessed by actigraphy data and self-report. Should the actiwatch malfunction, reliance on self-report will suffice. If the subject does not meet this requirement, he will be asked to reschedule
• Must have refrained from consumption of stimulants (including caffeine) and over the counter medications which may induce drowsiness for a minimum of 16 hours prior to each test session, and nicotine, 8 hours, prior to all testing sessions, assessed by self-report.

Exclusion Criteria:

• Currently taking medications which induce drowsiness, such as over-the-counter antihistamines. Any self-medication will be assessed through self-report.
• No current medical conditions or medications affecting cognitive function or attention as determined by screening by study physician or medical practitioner
• Current or recent use (as determined by study physician or medical practitioner) of medications that may interact with the test articles. Determined by self-report and exclusion at the discretion of the study physician or medical practitioner.
• Any history of any attention deficit condition requiring medication. A history of any attention deficit condition with medication is disqualifying as the potential interactions with testing are unknown and would therefore produce a potential source of confounding or bias into the results of the study.
• Any history of psychological/psychiatric disorder.
• Any history of addiction or substance abuse as assessed through self-report.
• Any history of metabolic disorder such as dysthyriodism.
• Any history of significant cardiovascular disease or hypertension.
• Any history of hepatic or renal disorder.
• Females will be excluded given that the drugs administered could potentially negatively impact the very early stages of pregnancy.
• Any ingestion of substances that may interact with the test articles or potentially skew the results within the last 16 hours prior to testing including over-the-counter medications, supplements, etc. (see attached list to be reviewed with subject).