An interventional study of HD-tDCS group and Conventional tDCS group in Stroke, sponsored by Chinese University of Hong Kong. Completed at 1 site in Hong Kong. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-09-13.
Sponsored by Chinese University of Hong Kong · Not applicable, Interventional, and Treatment
Transcranial direct current stimulation (tDCS) had recently been shown having feasibility in modulating cortical excitability transiently during motor training in a noninvasive way. The findings support that tDCS and motor practice can positively promote post-stroke motor learning to improve upper-limb motor recovery after stroke. A randomized controlled trial will be conducted with three groups: HD-tDCS, conventional tDCS and sham HD-tDCS. A 10-session training will be provided to evaluate the effectiveness of transient modulation of cortical excitability through tDCS with clinical assessment scores.
7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.
This study's enrollment of 25 is below the median of 50 across 5,369 interventional studies indexed under Stroke.
Browse Stroke studies →Chinese University of Hong Kong is the lead sponsor of 1,419 studies on the registry; 487 are open to participants now.
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Constant current (1mA) will be applied for 20min and the anode will be placed over the defined target area
Device: HD-tDCS group
Constant current (1mA) will be applied for 20min and the anode will be placed over the standard C3/C4 position
Device: Conventional tDCS group
The stimulator will be shut down after 30s of stimulation. The patients will feel the initial itching sensation at the beginning in order to evaluate the placebo effect.
Device: Sham HD-tDCS group
5 sintered Ag/AgCl ring electrodes will be used at a radius of \~5cm. The electrodes will be placed inside plastic electrode holders which will be filled with gel to have better contact with the scalp.
A pair of 25 cm2 rubber electrodes enclosed in saline-soaked sponges and affixed to the head with rubber bands.
A pair of 25 cm2 rubber electrodes enclosed in saline-soaked sponges and affixed to the head with rubber bands.
Action Research Arm Test (ARAT)
The ARAT has total 19 items, divided into 4 categories (grasp, grip, pinch, and gross arm movement). It ranges from 3 to 0 (best to worse).
Time frame: 3-month after the 10th session training
Fugl-Meyer Assessment (Upper Extremity)
The maximum score is 66, divided into 33 items in the form of a 3-point scale (0-2), 0 is cannot perform and 2 performs fully.
Time frame: 3-month after the 10th session training
Wolf Motor Function Test (WMFT)
The WMFT measures upper limb ability through timed and functional tasks. It has 17 items, ranging from 0 to 5 (worse to best).
Time frame: 3-month after the 10th session training
Magnetic Resonance Imaging
Functional magnetic resonance imaging
Time frame: Baseline
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Sep 2021. You cannot join it, but the record below documents what was studied.
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Chinese University of Hong Kong