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Active, not recruitingNCT03829059Updated Nov 20, 2024

Histological/ Immunohistological and Molecularpathological Types of Epulides and Central Giant Cell Lesions of the Jaws

An observational study in Epulis, sponsored by Medical University of Graz. Active, not recruiting at 1 site in Austria. Open to participants aged 7 Years to 95 Years. Per ClinicalTrials.gov, last updated 2024-11-20.

Sponsored by Medical University of Graz · Observational

From the registry’s dates

  • Primary completion was expected by Feb 2026, 8 months ago, but the record still lists the study as active, not recruiting.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
83
Ages
7 Years to 95 Years
Sex
All
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Study summary

This retrospective study will evaluate the patient collective of the Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health and of the Division of Cranio-Maxillofacial Surgery at the Medical University Graz concerning the frequency of epulis/giant cell lesion or underlying differential diagnoses and immunophenotypes as well as the resulting treatment methods and their success and compare these with international results

Read the detailed description

Different histopathological differential diagnoses can underlay the clinical presentation of an epulis. Often the immunophenotype of these lesions is of particular importance. This also holds for the the central giant cell lesion.

This study will evaluate the patient collective of the Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health and of the Division of Cranio-Maxillofacial Surgery at the Medical University Graz concerning the frequency of epulis/giant cell lesion or underlying differential diagnoses and immunophenotypes as well as the resulting treatment methods and their success and compare these with international results.

This is a retrospective study using electronic patient records, written records, operative reports of the Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health and of the Division of Cranio-Maxillofacial Surgery at the Medical University Graz in the period from 1986 to March 2018. It is intended to gather the data within 12 months and analyze statistically subsequently.

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Conditions studied

  • Epulis

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03

In context

Gingival Diseases

84 studies on the registry are indexed under Gingival Diseases; 25 are open to participants now.

This study's enrollment of 83 is below the median of 108 across 17 observational studies indexed under Gingival Diseases.

Browse Gingival Diseases studies →

Lead sponsor

Medical University of Graz is the lead sponsor of 459 studies on the registry; 98 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
7 Years to 95 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The patient cohort comprises 101 patients treated in the outpatient clinic for diseases of oral mucosa of the Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health and of the Division of Cranio-Maxillofacial Surgery at the Medical University Graz in the period from 1986 to March 2018.

Inclusion criteria

  • existence of a medical history and a histopathological finding of the surgical specimen
  • patients treated in the outpatient clinic for diseases of oral mucosa of the Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health and of the Division of Cranio-Maxillofacial Surgery at the Medical University Graz between 1986 and March 2018

Exclusion criteria

Exclusion Criteria:

  • absence of a medical history or a histopathological finding.
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
83 participants (actual)
Patient registry
No
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What researchers measure

Primary outcomes

  1. Frequency of histological pathological differential diagnoses.

    Time frame: time period of evaluation from 1986 to March 2018

  2. Frequency of immunohistochemical pathological differential diagnoses.

    Time frame: time period: from 1986 to March 2018

  3. Frequency of molecular pathological differential diagnoses.

    Time frame: time period from 1986 to March 2018

Secondary outcomes

  1. Frequency of recurrences

    depending on differential diagnoses and therapy

    Time frame: time period from 1986 to March 2018

07

Study locations

1 site
  • Medical University
    Graz, 8036, Austria
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 20, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03829059
Lead sponsor
Medical University of Graz
Responsible party
Sponsor
First posted
Feb 4, 2019
Start date
Jun 1, 2018
Primary completion
Feb 2026 (estimated)
Completion
Feb 2026 (estimated)
Last update
Nov 20, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Nov 2024. You cannot join it, but the record below documents what was studied.

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