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CompletedNCT03823222ProDuckTUpdated Apr 16, 2019

Proteins From Duckweed Trial

An interventional study of Duckweed protein and Whey protein in Degree of Digestilbility, sponsored by Wageningen University and Research. Completed at 1 site in Netherlands. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-04-16.

Sponsored by Wageningen University and Research · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
12
Allocation
Randomized
Ages
18 Years to 50 Years
Sex
All
01

Study summary

This study aims to study the digestibility of isolated duckweed protein. The digestibility of the isolated duckweed protein will be compared to an isolated benchmark protein whey.

Objective: The primary objective is to investigate the digestibility of isolated duckweed protein and the isolated benchmark protein whey.

Study design: The study is a cross-over, double blind, controlled trial in which study participants will visit the research facility on two occasions under fasting conditions. Subjects will receive two protein sources in randomized order with a washout period of one week. Blood will be collected via a catheter before and up-to 3 hours after protein consumption.

Study population: We aim to include 12 healthy volunteers aged 18-50 years. Intervention: Study participants will receive 20 grams of isolated duckweed protein and the isolated benchmark protein whey.

Main study parameters/endpoints: The main study parameter is blood amino acids measured before and after consumption of 20 g protein.

02

Conditions studied

  • Degree of Digestilbility

Keywords

  • Duckweed protein
  • protein
  • degree of digestibility
  • whey protein
03

In context

Lead sponsor

Wageningen University and Research is the lead sponsor of 31 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Body mass index (BMI) between 18 and 25 kg/m2
  • Having veins suitable for blood sampling via a catheter (judged by study nurse/ medical doctor)

Exclusion criteria

Exclusion Criteria:

  • Any metabolic, gastrointestinal, inflammatory or chronic disease (such as diabetes, anaemia, hepatitis, cardiovascular disease)
  • History of gastro-intestinal surgery or having (serious) gastro-intestinal complaints
  • History of liver dysfunction (cirrhosis, hepatitis) or liver surgery
  • Kidney dysfunction (self-reported)
  • Use of medication that may influence the study results, such as gastric acid inhibitors, laxatives, stomach protectors and drugs that can affect intestinal motility
  • Anaemia (Hb values \<7.5 for women and \<8.5 for men)
  • Reported slimming, medically prescribed, vegan/vegetarian or other extreme diets or the use of protein supplements
  • Not willing to give up blood donation during the study
  • Current smokers
  • Alcohol intake ≥4 glasses of alcoholic beverages per day
  • Pregnant, lactating or wishing to become pregnant in the period of the study (self-reported)
  • Abuse of illicit drugs
  • Food allergies for products that we use in the study
  • Participation in another clinical trial at the same time
  • Being an employee of the department Consumer Science \& Health group of Wageningen Food \& Biobased Research
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Investigator)
Enrollment
12 participants (actual)

Study arms

  • Experimental
    Duckweed protein

    20 gram of isolated protein

    Dietary Supplement: Duckweed protein

  • Experimental
    Whey protein

    20 gram of isolated protein

    Dietary Supplement: Whey protein

Interventions

  • Dietary supplementDuckweed protein

    20 grams isolated protein

  • Dietary supplementWhey protein

    20 grams isolated protein

06

What researchers measure

Primary outcomes

  1. Change in blood free amino acids (e.g. Degree of digestibility)

    postprandial test, determine free amino acids in blood samples collected before and after a postprandial challenge test

    Time frame: 20 gram protein will be consumed and blood samples will be taken before and up to 3 hours after protein consumption

Secondary outcomes

  1. change in plasma insulin

    before and after a postprandial challenge test

    Time frame: 20 gram protein will be consumed and blood samples will be taken before and up to 3 hours after protein consumption

  2. change in plasma glucose

    before and after a postprandial challenge test

    Time frame: 20 gram protein will be consumed and blood samples will be taken before and up to 3 hours after protein consumption

Other outcomes

  1. change in visual analogue scale (VAS) scores on intestinal complains

    On a scale ranging from worst-best outcome (higher scores are better)

    Time frame: daily from day1 until day3 after the intervention

07

Study locations

1 site
  • Stichting Wageningen Research
    Wageningen, Gelderland 6708 WG, Netherlands
08

References and documents

Individual participant data

Plan to share: No — will not be shared

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 16, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03823222
Lead sponsor
Wageningen University and Research
Responsible party
Diederik Esser (project leader clinical trials, Wageningen University and Research) — Principal investigator
First posted
Jan 30, 2019
Start date
Feb 28, 2019
Primary completion
Mar 28, 2019
Completion
Mar 28, 2019
Last update
Apr 16, 2019

Study contacts

Diederik Esser, PhD
principal investigator · Wageningen Research

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.

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