An interventional study of Whole grain oats and Whole grain wheat in Healthy Volunteers, sponsored by USDA Beltsville Human Nutrition Research Center. Completed at 1 site in United States. Open to participants aged 21 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-07-05.
Sponsored by USDA Beltsville Human Nutrition Research Center · Not applicable, Interventional, and Other
The primary objective of this study is to identify markers of a single meal of whole grain oat and whole grain wheat intake in humans.
The aim of this study is to identify compounds that are found in blood and urine and are derived from a single meal of whole grain oat or whole grain wheat intake so that epidemiological studies can be conducted to provide more accurate associations between whole grain intake and health.
USDA Beltsville Human Nutrition Research Center is the lead sponsor of 29 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Volunteers will consume a breakfast meal containing whole grain oats after 7 days of a whole grain free diet.
Other: Whole grain oats
Volunteers will consume a breakfast meal containing whole grain wheat after 7 days of a whole grain free diet.
Other: Whole grain wheat
A meal containing whole grain oats
A meal containing whole grain wheat
Identification of unknown biomarkers of grain intake immediately after grain consumption
Blood and Urine metabolomics profiling will be conducted. Metabolomics refers to the complete set of small molecule metabolites. The METLIN Metabolomics Database is a repository of such chemicals and contains over 75,000 entries, thus metabolomics is a very broad assessment. Blood and urine will be broadly analyzed with mass spectrometers for metabolomics, and all ionizing compounds will be captured by the detector, which reports the ratio of mass of the compound to the charge (units: m/z which is mass to charge). The mass-to-charges will be compared across different time points of collection, and appearance of mass-to-charges in some collections (but not found in others when grains were not consumed) will indicate a biomarker of grain intake.
Time frame: Day 8
Identification of unknown biomarkers of grain intake a day after grain consumption
Blood and Urine metabolomics profiling will be conducted. Metabolomics refers to the complete set of small molecule metabolites. The METLIN Metabolomics Database is a repository of such chemicals and contains over 75,000 entries, thus metabolomics is a very broad assessment. Blood and urine will be broadly analyzed with mass spectrometers for metabolomics, and all ionizing compounds will be captured by the detector, which reports the ratio of mass of the compound to the charge (units: m/z which is mass to charge). The mass-to-charges will be compared across different time points of collection, and appearance of mass-to-charges in some collections (but not found in others when grains were not consumed) will indicate a biomarker of grain intake.
Time frame: Day 9
Identification of unknown biomarkers of grain intake 2 days after grain consumption
Urine metabolomics profiling will be conducted. Metabolomics refers to the complete set of small molecule metabolites. The METLIN Metabolomics Database is a repository of such chemicals and contains over 75,000 entries, thus metabolomics is a very broad assessment. Urine will be broadly analyzed with mass spectrometers for metabolomics, and all ionizing compounds will be captured by the detector, which reports the ratio of mass of the compound to the charge (units: m/z which is mass to charge). The mass-to-charges will be compared across different time points of collection, and appearance of mass-to-charges in some collections (but not found in others when grains were not consumed) will indicate a biomarker of grain intake.
Time frame: Day 10
Identification of unknown biomarkers of grain intake immediately after grain consumption
Blood and Urine metabolomics profiling will be conducted. Metabolomics refers to the complete set of small molecule metabolites. The METLIN Metabolomics Database is a repository of such chemicals and contains over 75,000 entries, thus metabolomics is a very broad assessment. Blood and urine will be broadly analyzed with mass spectrometers for metabolomics, and all ionizing compounds will be captured by the detector, which reports the ratio of mass of the compound to the charge (units: m/z which is mass to charge). The mass-to-charges will be compared across different time points of collection, and appearance of mass-to-charges in some collections (but not found in others when grains were not consumed) will indicate a biomarker of grain intake.
Time frame: Day 34
Identification of unknown biomarkers of grain intake a day after grain consumption
Blood and Urine metabolomics profiling will be conducted. Metabolomics refers to the complete set of small molecule metabolites. The METLIN Metabolomics Database is a repository of such chemicals and contains over 75,000 entries, thus metabolomics is a very broad assessment. Blood and urine will be broadly analyzed with mass spectrometers for metabolomics, and all ionizing compounds will be captured by the detector, which reports the ratio of mass of the compound to the charge (units: m/z which is mass to charge). The mass-to-charges will be compared across different time points of collection, and appearance of mass-to-charges in some collections (but not found in others when grains were not consumed) will indicate a biomarker of grain intake.
Time frame: Day 35
Identification of unknown biomarkers of grain intake 2 days after grain consumption
Urine metabolomics profiling will be conducted. Metabolomics refers to the complete set of small molecule metabolites. The METLIN Metabolomics Database is a repository of such chemicals and contains over 75,000 entries, thus metabolomics is a very broad assessment. Urine will be broadly analyzed with mass spectrometers for metabolomics, and all ionizing compounds will be captured by the detector, which reports the ratio of mass of the compound to the charge (units: m/z which is mass to charge). The mass-to-charges will be compared across different time points of collection, and appearance of mass-to-charges in some collections (but not found in others when grains were not consumed) will indicate a biomarker of grain intake.
Time frame: Day 36
Blood glucose
Blood glucose will be measured. Blood glucose is reported in mmol/L.
Time frame: Days 8 and 34
Serum insulin
Serum insulin will be measured. Serum insulin is reported in mIU/L.
Time frame: Days 8 and 34
Serum c-peptide
Serum c-peptide will be measured. Serum c-peptide is reported in ng/ml.
Time frame: Days 8 and 34
Non-esterified fatty acids in blood
Non-esterified fatty acids will be measured in blood. Non-esterified fatty acids are reported as mEQ/L.
Time frame: Days 8 and 34
Triglycerides in blood
Triglycerides will be measured. Triglycerides are reported as mmol/L.
Time frame: Days 8 and 34
Plan to share: No
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This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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USDA Beltsville Human Nutrition Research Center