An interventional study of Bicarbonate-buffered handling medium in Infertility, sponsored by Muhammad Fawzy. Completed at 3 sites in Egypt. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2019-08-07.
Sponsored by Muhammad Fawzy · Not applicable, Interventional, and Other
The pH stability during human gamete handling for intracytoplasmic sperm injection (ICSI) is physiologically sound. As the pH change for bicarbonate-buffered medium, scientists assumed whether the use of HEPES or MOPS buffered medium would provide more stable pH, thereby better outcomes. However, the oil use and time frame outside the incubators have not been accounted for. This study is to evaluate the use of HEPES buffered medium compared with the bicarbonate-buffered medium on ICSI outcomes.
2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.
This study's enrollment of 1,057 is above the median of 120 across 1,698 interventional studies indexed under Infertility.
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Exclusion Criteria:
Other: Bicarbonate-buffered handling medium
The investigators will evaluate whether the usual bicarbonate culture medium can replace the HEPES buffered medium effectively.
live birth rate
viable neonate after 30 weeks of Gestation
Time frame: 40 weeks
Clinical pregnancy rate
a positive heartbeat on ultrasound at ≥ 7 weeks of gestation
Time frame: 12 weeks
biochemical pregnancy rate
positive b-hCG at ≥ 14 days following embryo transfer
Time frame: two weeks
embryo developmental rates
fertilized oocyte per injected ones and developed embryos per fertilized oocytes
Time frame: 6 days of culture
Ongoing pregnancy rate
Continued pregnancy after week 12 of gestation
Time frame: 16 weeks
Plan to share: No
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This study is completed, as verified in Aug 2019. You cannot join it, but the record below documents what was studied.
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