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RecruitingNCT03775837Updated Jun 4, 2025

Effect of Panax Ginseng C.A. Mey Extract on Liver Function in Adults

An interventional study of Panax Ginseng C.A. Mey Extract group and Placebo group in Liver Diseases, sponsored by Pusan National University Yangsan Hospital. Recruiting at 1 site in Korea, Republic of. Open to participants aged 19 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-06-04.

Sponsored by Pusan National University Yangsan Hospital · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Dec 2025, 9 months ago, but the record still lists the study as recruiting.
  • Started Dec 2018; still recruiting 7 years 10 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
19 Years to 75 Years
Sex
All
01

Study summary

The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Panax Ginseng C.A. Mey Extract on liver function in adults for 8 weeks.

Read the detailed description

Previous studies have indicated that Panax Ginseng C.A. Mey Extract may have the ability to improve liver function. Therefore, the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the Panax Ginseng C.A. Mey Extract on liver function in adults; the safety of the compound are also evaluate. The Investigators examine AST, ALT, GGT, and other metabolic parameters at baseline, as well as after 4 and 8 weeks of intervention. Sixty adults were administered either 600 mg of Panax Ginseng C.A. Mey Extract or a placebo each day for 8 weeks;

02

Conditions studied

  • Liver Diseases

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03

In context

Liver Diseases

2,081 studies on the registry are indexed under Liver Diseases; 390 are open to participants now.

This study's planned enrollment of 60 is above the median of 50 across 1,323 interventional studies indexed under Liver Diseases.

Browse Liver Diseases studies →

Lead sponsor

Pusan National University Yangsan Hospital is the lead sponsor of 106 studies on the registry; 27 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
19 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • ALT ranging from upper limit of reference to three times of upper limit

Exclusion criteria

Exclusion Criteria:

  • Abnormal liver or renal function (i.e., serum aminotransferase activity > 3 times of upper limit of reference range and serum creatinine concentrations > 1.2 mg/dL)
  • Diabetes (diagnosed clinically or fasting glucose level > 126 mg/dL)
  • History of viral hepatitis or cancer
  • Uncontrolled hypertension
  • History of serious cardiac disease such as angina or myocardial infarction
  • History of gastrectomy
  • History of medication for psychiatric disease
  • Administration of oriental medicine including herbs within the past 4 weeks
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Care provider, Investigator)
Enrollment
60 participants (estimated)

Study arms

  • Experimental
    Panax Ginseng C.A. Mey Extract group

    This group takes Panax Ginseng C.A. Mey Extract for 8 weeks

    Dietary Supplement: Panax Ginseng C.A. Mey Extract group

  • Placebo comparator
    Placebo group

    This group takes placebo for 8 weeks

    Dietary Supplement: Placebo group

Interventions

  • Dietary supplementPanax Ginseng C.A. Mey Extract group

    This group takes Panax Ginseng C.A. Mey Extract for 8 weeks

  • Dietary supplementPlacebo group

    This group takes placebo for 8 weeks

06

What researchers measure

Primary outcomes

  1. Alanine aminotransferase

    Alanine aminotransferase

    Time frame: 8 weeks

Secondary outcomes

  1. Aspartate aminotransferase

    Aspartate aminotransferase

    Time frame: 8 weeks

  2. Gamma-glutamyl transferase

    Gamma-glutamyl transferase

    Time frame: 8 weeks

07

Study locations

1 of 1 sites recruiting
  • Integrated Research Institute for Natural Ingredients and Functional Foods
    Yangsan, 50612, Korea, Republic of
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 4, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03775837
Lead sponsor
Pusan National University Yangsan Hospital
Responsible party
Sang Yeoup Lee (Professor, Pusan National University Yangsan Hospital) — Principal investigator
First posted
Dec 14, 2018
Start date
Dec 1, 2018
Primary completion
Dec 30, 2025 (estimated)
Completion
Dec 31, 2025 (estimated)
Last update
Jun 4, 2025

Study contacts

Sang Yeoup Lee
Contact
saylee@pnu.edu
360-2860 ext. 055
Ye Li Lee
Contact
yeri1230@gmail.com
360-2860 ext. 055
Sang Yeoup Lee
principal investigator · Pusan National University Yangsan Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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