CClinicalTrials.gg
Status unknownNCT03764917Updated Mar 24, 2020

NGS Combined With RNAseq on Tumor Immune Escape in NSCLC

An observational study in Non-small Cell Lung Cancer, sponsored by Shanghai Pulmonary Hospital, Shanghai, China. Status unknown at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2020-03-24.

Sponsored by Shanghai Pulmonary Hospital, Shanghai, China · Observational

The sponsor has not verified this record recently (last verified Mar 2020), so the status shown — last known as Active, not recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
100
Ages
18 Years to 75 Years
Sex
All
01

Study summary

Study on the tumor immune escape in advanced non-small cell lung cancer patients with EGFR and ALK mutant negative by NGS combined with RNAseq

Read the detailed description

Study on the tumor immune escape in advanced non-small cell lung cancer patients with EGFR and ALK mutant negative by NGS combined with RNAseq. Detecting non-small cell lung cancer patient NGS and RNAseq data before first-line chemotherapy, after two cycles chemotherapy and after disease progression.

02

Conditions studied

  • Non-small Cell Lung Cancer

Keywords

  • NGS
  • RNAseq
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In context

Lung Neoplasms

7,243 studies on the registry are indexed under Lung Neoplasms; 1,557 are open to participants now.

This study's planned enrollment of 100 is below the median of 189 across 1,514 observational studies indexed under Lung Neoplasms.

Browse Lung Neoplasms studies →

Lead sponsor

Shanghai Pulmonary Hospital, Shanghai, China is the lead sponsor of 149 studies on the registry; 91 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Non-small cell lung cancer patient First-line chemotherapy with platinum-based chemotherapy Without EGFR and Alk mutation

Inclusion criteria

Non-small cell lung cancer patient First-line chemotherapy with platinum-based chemotherapy

Exclusion criteria

Exclusion Criteria:

EGFR mutant positive Alk mutant positive

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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No

Interventions

  • OtherTime

    Different detecting time

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What researchers measure

Primary outcomes

  1. numbers of immune cells

    detecting numbers of immune cells before first-line chemotherapy, after two cycles chemotherapy and after disease progression

    Time frame: 24 months

Secondary outcomes

  1. numbers of tumor mutations

    detecting numbers of tumor mutations before first-line chemotherapy, after two cycles chemotherapy and after disease progression

    Time frame: 24 months

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Study locations

1 site
  • Shanghai Pulmonary Hospital
    Shanghai, Shanghai 200000, China
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References and documents

Publications

  • He Y, Chen L, Zhao L, Dang S, Liu G, Sasada S, Ma PC, van Zandwijk N, Rosell R, Popper HH, Wang H, Jiang M, Guo H, Liu X, Chen S, Zhang X, Xu M, Zhu B, Liu M, Zhou C. Genomic and transcriptional alterations in first-line chemotherapy exert a potentially unfavorable influence on subsequent immunotherapy in NSCLC. Theranostics. 2021 May 13;11(14):7092-7109. doi: 10.7150/thno.58039. eCollection 2021. PubMed 34093873 ↗

Individual participant data

Plan to share: Undecided

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 24, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03764917
Lead sponsor
Shanghai Pulmonary Hospital, Shanghai, China
Responsible party
Caicun Zhou (Prof. Caicun Zhou, Shanghai Pulmonary Hospital, Shanghai, China) — Principal investigator
First posted
Dec 5, 2018
Start date
Dec 1, 2018
Primary completion
Dec 31, 2020 (estimated)
Completion
Dec 31, 2021 (estimated)
Last update
Mar 24, 2020

Study contacts

Yayi He, MD, PHD
principal investigator · Shanghai Pulmonary Hospital, Tongji University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.

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