An interventional study of venous blood sampling and spleen volumetry in Celiac Disease, sponsored by University Hospital Hradec Kralove. Status unknown at 1 site in Czechia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-12-04.
Sponsored by University Hospital Hradec Kralove · Not applicable, Interventional, and Diagnostic
This project is expected to confirm the hypothesis that hyposplenism in patients with celiac disease is not conditioned by a selective memory deficiency of B lymphocytes.
Other objectives of project are:
Ultrasound examination is focused to spleen size (spleen volumetry). Methodology of laboratory examinations is based on venous blood sampling for the determination of memory B-like marginal zone by flow cytometry; gliadin 33-mer (ELISA) determination in faecal and urine sample; blood plasma extraction for citrulline (high performance liquid chromatography, HPLC).
333 studies on the registry are indexed under Celiac Disease; 78 are open to participants now.
This study's planned enrollment of 50 is close to the median of 50 across 203 interventional studies indexed under Celiac Disease.
Browse Celiac Disease studies →University Hospital Hradec Kralove is the lead sponsor of 47 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Ultrasound examination: scaled to spleen size (spleen volumetry) Methodology of laboratory tests: venous blood sampling
Diagnostic Test: venous blood sampling · Procedure: spleen volumetry
No intervention in this group.
Venous blood samples to determine memory B lymphocytes.
Ultrasound examination of spleen to scaled the size.
concentration of B-lymphocytes as parameter to evaluate treatment effect
assessment method: blood sampling, units: the measurement results are in absolute numbers, method: flow cytometry
Time frame: one year
concentration of B-lymphocytes as parameter to evaluate treatment effect
assessment method: blood sampling, units: the measurement results are in percentage numbers, method: flow cytometry
Time frame: one year
concentration of citrullin in plasma as parameter to evaluate treatment effect
assessment method: blood sampling, units: μmol/l (micromol/l; Citrullin cut-off for intestinal failure is \<20μmol / L), method: mass spectrometry (LC-MS instrumentation with internal isotopically labeled standard)
Time frame: one year
concentration of ornithin in plasma as parameter to evaluate treatment effect
assessment method: blood sampling, units: μmol/l (micromol/l), method: mass spectrometry (LC-MS instrumentation with internal isotopically labeled standard)
Time frame: one year
Plan to share: Undecided
This study is status unknown, as verified in Dec 2018. You cannot join it, but the record below documents what was studied.
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University Hospital Hradec Kralove