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CompletedNCT03750799CTEWBWUpdated Apr 18, 2019

Cross-training Effect of Whole-body Vibration

An interventional study of Whole body vibration and Sham vibration in Muscle Physiology, sponsored by Istanbul Physical Medicine Rehabilitation Training and Research Hospital. Completed at 1 site in Turkey. Open to male participants aged 20 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-04-18.

Sponsored by Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
20 Years to 50 Years
Sex
Male
01

Study summary

This study evaluates whether an increase in the ipsilateral knee flexor muscle strength transfers to the contralateral knee extensors which are not exposed to vibration, when unilateral-isolated whole body vibration (WBV) is applied to the lower extremity. In the half of volunteers the right leg were exposed vibration, while in the other half the right leg were exposed sham vibration. Muscle strength were measured with the Cybex® (Massachusetts, USA) extremity-testing system.

Read the detailed description

This study was included 40 healthy volunteers. The change in the quadriceps muscle strength after 20 session of WBV exercises was evaluated this study. In the WBV group, 20 sessions of unilateral lower extremity vibration exercises were performed with the Whole Body Vibration (WBV) device. WBV was applied when the subjects are in the semi-squat position. WBV was implemented with Powerplate® Pro5 (PowerPlate® International Ltd, London, United Kingdom). During 20 sessions, the WBV amplitude and vibration time were increased gradually. In the first session, the subjects were do a 30-second, 30-35, 40- and 45-Hz low-amplitude WBV while the knee and hip joint were in 30 degrees of flexion (in the semi-squat position); 10-second rest period between vibration applications were applied. A total duration of WBV was be two minutes. In the 20th session, the subjects were given a 60-second, 30-, 35-, 40- and 45-Hz high-amplitude WBV while the knee and hip joint were in 45 degrees of flexion; 10-second rest period between vibration applications were applied. A total duration of WBV was eight minutes. During WBV, the left lower extremity was in the knee-hip flexion position but was not exposed the vibration.

The same experimental protocol was applied to the isometric exercise (control) group. Unlike the experimental group, sham vibration was applied to the control group. Before and after 20 session-exercise, both knee extensor isokinetic muscle strength was measured.

02

Conditions studied

  • Muscle Physiology
03

In context

Lead sponsor

Istanbul Physical Medicine Rehabilitation Training and Research Hospital is the lead sponsor of 119 studies on the registry; 27 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 50 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Inclusion criteria

  • Men with ages between 20-50 years
  • Being healthy
  • Being volunteer
  • Right-sided dominant

Exclusion criteria

Exclusion Criteria:

  • Non-cooperative subject
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
40 participants (actual)

Study arms

  • Experimental
    Experimental group

    Whole body vibration was applied on the right lower extremity.

    Device: Whole body vibration

  • Sham comparator
    Sham group

    Unlike the experimental group, sham vibration was applied to the control group.

    Device: Sham vibration

Interventions

  • DeviceWhole body vibration

    Whole body vibration was applied on the right lower extremity in the experimental group.

  • DeviceSham vibration

    Sham vibration was applied on the right lower extremity in the Control sham group

06

What researchers measure

Primary outcomes

  1. Muscle strength gain of the untrained contralateral quadriceps muscle

    Untrained contralateral quadriceps muscle strength was measured with the Cybex extremity-testing system before and after trial. Unit of this parameter was Nm

    Time frame: four months

07

Study locations

1 site
  • Istanbul Physical Medicine Rehabilitation Training and Research Hospital
    Istanbul, Turkey
08

References and documents

Publications

  • Karacan I, Cidem M, Cidem M, Turker KS. Whole-body vibration induces distinct reflex patterns in human soleus muscle. J Electromyogr Kinesiol. 2017 Jun;34:93-101. doi: 10.1016/j.jelekin.2017.04.007. Epub 2017 Apr 24. PubMed 28457998 ↗
  • Karacan I, Cidem M, Yilmaz G, Sebik O, Cakar HI, Turker KS. Tendon reflex is suppressed during whole-body vibration. J Electromyogr Kinesiol. 2016 Oct;30:191-5. doi: 10.1016/j.jelekin.2016.07.008. Epub 2016 Jul 25. PubMed 27485766 ↗
  • Cakar HI, Cidem M, Sebik O, Yilmaz G, Karamehmetoglu SS, Kara S, Karacan I, Turker KS. Whole-body vibration-induced muscular reflex: Is it a stretch-induced reflex? J Phys Ther Sci. 2015 Jul;27(7):2279-84. doi: 10.1589/jpts.27.2279. Epub 2015 Jul 22. PubMed 26310784 ↗
  • Karamehmetoglu SS, Karacan I, Cidem M, Kucuk SH, Ekmekci H, Bahadir C. Effects of osteocytes on vibration-induced reflex muscle activity in postmenopausal women. Turk J Med Sci. 2014;44(4):630-8. PubMed 25551934 ↗
  • Cidem M, Karacan I, Diracoglu D, Yildiz A, Kucuk SH, Uludag M, Gun K, Ozkaya M, Karamehmetoglu SS. A Randomized Trial on the Effect of Bone Tissue on Vibration-induced Muscle Strength Gain and Vibration-induced Reflex Muscle Activity. Balkan Med J. 2014 Mar;31(1):11-22. doi: 10.5152/balkanmedj.2013.9482. Epub 2014 Mar 1. PubMed 25207162 ↗
  • Cakar HI, Cidem M, Kara S, Karacan I. Vibration paradox and H-reflex suppression: is H-reflex suppression results from distorting effect of vibration? J Musculoskelet Neuronal Interact. 2014 Sep;14(3):318-24. PubMed 25198227 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 18, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03750799
Lead sponsor
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Responsible party
Ilhan KARACAN (Researcher, Assoc Prof, Istanbul Physical Medicine Rehabilitation Training and Research Hospital) — Principal investigator
First posted
Nov 23, 2018
Start date
Nov 12, 2018
Primary completion
Jan 1, 2019
Completion
Feb 1, 2019
Last update
Apr 18, 2019

Study contacts

Ilhan Karacan, Assoc Prof
study chair · Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.

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