CClinicalTrials.gg
RecruitingNCT03746964MECATHORUpdated Jan 9, 2026

Prospective Evaluation of the Biomechanical Properties of the Thoracic Aorta Coupling Magnetic Resonance Imaging and In-vitro Elasticity Tests in Patients With Ascending Aortic Aneurysm

An observational study in Patient With Ascending Aortic Aneurysm With Surgical Indication for Replacement, sponsored by Centre Hospitalier Universitaire Dijon. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-09.

Sponsored by Centre Hospitalier Universitaire Dijon · Observational

From the registry’s dates

  • Started Dec 2018; still recruiting 7 years 9 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Ages
18 Years and older
Sex
All
01

Study summary

The biomechanical properties of the aorta are currently poorly understood. A better understanding would optimize surgical indications and monitoring techniques for patients with thoracic aortic aneurysms.

02

Conditions studied

  • Patient With Ascending Aortic Aneurysm With Surgical Indication for Replacement
03

In context

Lead sponsor

Centre Hospitalier Universitaire Dijon is the lead sponsor of 495 studies on the registry; 105 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patient in preoperative consultation in the cardiovascular and thoracic surgery department.

Inclusion criteria

  • Person who has given oral consent
  • Patient with ascending aortic aneurysm with surgical indication for replacement
  • Age > 18 years old
  • Scheduled surgery

Exclusion criteria

Exclusion Criteria:

  • Person not affiliated to the national health insurance system
  • Protected adult
  • Pregnant or breastfeeding woman
  • MRI Contraindication
  • Emergency surgical procedure
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (estimated)
Patient registry
No

Interventions

  • ProcedureCardiac MRI

    Preoperative cardiac MRI

  • Otherin-vitro elasticity tests

    in-vitro elasticity tests performed on a segment of ascending aorta collected during surgery

06

What researchers measure

Primary outcomes

  1. aortic compliance by cardiac MRI

    Time frame: Before surgery

  2. In-vitro testing of the elasticity of the aortic wall fragment collected during surgery.

    Time frame: through study completion, an average of 12 months

07

Study locations

1 of 1 sites recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 9, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT03746964
Lead sponsor
Centre Hospitalier Universitaire Dijon
Responsible party
Sponsor
First posted
Nov 20, 2018
Start date
Dec 17, 2018
Primary completion
Dec 2026 (estimated)
Completion
Feb 2027 (estimated)
Last update
Jan 9, 2026

Study contacts

Comlan BLITTI
Contact
comlanmawuko.blitti@chu-dijon.fr
+33 3 80 29 33 52

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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