CClinicalTrials.gg
CompletedNCT03709238Updated Mar 31, 2022

Pain Processing and Pain Reporting in Patients With Alzheimer's Disease

An observational study in Pain, sponsored by University of Aarhus. Completed at 1 site in Denmark. Open to participants aged 50 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-03-31.

Sponsored by University of Aarhus · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
47
Ages
50 Years and older
Sex
All
01

Study summary

The study investigates pain processing and pain reporting in patients with Alzheimers disease compared to healthy participants.

Employing a within-subject design, the study includes patients with Alzheimers disease and healthy participants that are exposed to thermal stimuli. During the test session the facial expressions of the participant are video recorded.

By repeating this on separate test days, the involvement of pain relief and pain increase is investigated.

02

Conditions studied

  • Pain

Browse trials for

Keywords

  • Pain
  • Alzheimers disease
03

In context

Alzheimer Disease

3,678 studies on the registry are indexed under Alzheimer Disease; 869 are open to participants now.

This study's enrollment of 47 is below the median of 200 across 751 observational studies indexed under Alzheimer Disease.

Browse Alzheimer Disease studies →

Lead sponsor

University of Aarhus is the lead sponsor of 1,274 studies on the registry; 183 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

  1. Patients with Alzheimers disease
  2. Healthy participants

Inclusion criteria

  • Mild to moderate patients with Alzheimers disease (group 1)
  • Healthy participants ( group 2)

Exclusion criteria

Exclusion Criteria:

  • Chronic pain conditions
  • Other medical, psychiatric or neurological disorders
  • Use of pain-reliving medication 24 hours prior to testing
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
47 participants (actual)
Patient registry
No

Groups and cohorts

  • Alzheimers diseased patients

    Behavioral: Different thermal stimulation. Recording of facial expression during thermal stimulation.

    Behavioral: Thermal stimulation

  • Healthy participants

    Behavioral: Different thermal stimulation. Recording of facial expression during thermal stimulation.

    Behavioral: Thermal stimulation

Interventions

  • BehavioralThermal stimulation

    Thermal stimulation

06

What researchers measure

Primary outcomes

  1. Numerical rating scale (NRS)

    Acute pain assessed on numerical rating scale from 0 (no pain experience) to 10 (worst pain), examining pain intensity. The participant will provide a number on the scale which reflects their pain intensity.

    Time frame: Participants will be tested on three different days. The numerical rating scale will be applied after each thermal stimulus for each test session.

Secondary outcomes

  1. Pain Assessment in persons with Impaired Cognition (PAIC)

    Video recordings will be analyzed with the PAIC scale from 0 (not at all) to 3 (great degree).

    Time frame: Participants will be video recorded on each of the three test days during testing.

07

Study locations

1 site
  • Department of Psychology and Behavioural Sciences
    Aarhus, Midtjylland 8000, Denmark
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 31, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03709238
Lead sponsor
University of Aarhus
Responsible party
Sponsor
First posted
Oct 17, 2018
Start date
Jan 3, 2019
Primary completion
Aug 31, 2021
Completion
Aug 31, 2021
Last update
Mar 31, 2022

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2021. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion