An interventional study of HD-tDCS in Healthy, sponsored by Brooklyn College of the City University of New York. Status unknown at 1 site in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-07-10.
Sponsored by Brooklyn College of the City University of New York · Not applicable, Interventional, and Basic science
When people learn and remember information, it is often accompanied by a feeling of subjective confidence about whether or not information has been learned and accurately remembered. These subjective feelings of confidence are often related to actual memory performance, but are sometimes incorrect. The investigators have previously shown that applying high definition transcranial direct current stimulation (HD-tDCS) over the dorsolateral prefrontal cortex leads to more accurate feelings of subjective confidence, at least when subjects are asked for their confidence about future memory performance. Accurate confidence judgments are useful in that they may later subsequent behavior, and inaccurate ones may be costly. For example, a student who erroneously believes that studied material was learned may stop studying and not do well on a test. Individuals who have a feeling-of-knowing about the answer to a general knowledge question will continue to search their memory, whereas individuals who do not have a feeling-of-knowing will stop searching their memory. Individuals who are confident they know the answer to a question are more likely to answer it. In this study, the experimenters are testing the effects of brain stimulation on subjective awareness of memory (termed metamemory monitoring) and how people use those subjective judgments (termed metamemory control). The approach taken is to have participants visit the laboratory on 3 visits and receive brain stimulation while completing memory and metamemory tasks.
Exclusion Criteria:
HD-tDCS will be applied over the DLPFC at 2mA in a single session for up to 30 min during the memory and metamemory task
Device: HD-tDCS
HD-tDCS will be applied over the DLPFC at 2mA in a single session for up to 30 min after the memory and metamemory task and during a filler task.
Device: HD-tDCS
Sham HD-tDCS will be applied over the DLPFC at 2mA in a single session for up to 30 min during the memory and metamemory task
Device: HD-tDCS
Participants will complete a metamemory and memory task
Also known as: Behavioral
Memory Control Advantage Index
This indexes the memory advantage for choosing which general knowledge question one receives a hint about the answer to versus having the experimenter choose which general knowledge question one receives a hint about the answer. The investigators will subtract the proportion of correctly recognized general knowledge answers for experimenter-chosen questions from the proportion correctly recognized for participant-chosen questions
Time frame: Through study completion, an average of 3 weeks
semantic recognition as assessed by a general knowledge task
Differences in recognition are compared between each condition (each active HD-tDCS and sham).
Time frame: Through study completion, an average of 3 weeks
semantic recall as assessed by a general knowledge task
Differences in recall are compared between each condition (each active HD-tDCS and sham).
Time frame: Through study completion, an average of 3 weeks
Feeling-of-knowing ratings and their accuracy
Feeling of knowing ratings are given on a scale. To assess the accuracy of these ratings, the subjective ratings are compared to objective accuracy, using signal detection based measures. Differences in feeling-of-knowing ratings and their accuracy are compared between each condition (each active HD-tDCS and sham).
Time frame: Through study completion, an average of 3 weeks
Plan to share: Undecided
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Brooklyn College of the City University of New York