A Phase 4 interventional study of immediate dental implant and Hyaluronic Acid in Immediate Dental Implant, sponsored by Ibrahim Samy Kalboush. Completed at 1 site in Egypt. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-06-08.
Sponsored by Ibrahim Samy Kalboush · Phase 4, Interventional, and Treatment
The high predictability of immediate dental implants has led to routine use with a great expectation for success.
Immediate implant placement in fresh extraction sockets was reported to reduce alveolar bone resorption, Better esthetic outcomes were achieved including the prosthetic crown length in harmony with the adjacent teeth, natural scalloping and easier distinct papillae to achieve and maximum soft tissue support.
hyaluronic acid can be placed in freshly extracted sockets immediately after tooth extraction , also it could be used on implant surface in which hyaluronic acid enhance new bone formation around dental implants.
Immediate dental implant placement was introduced more than 30 years ago by Schulte and Heimke in 1976.
The major advantages of immediate implant placement are reduction in number of visits, thus reduces the treatment time and improves patient satisfaction, provides ideal three dimensional implant position, and preserves the alveolar bone in the extraction socket
. However, immediate implants may have some disadvantages that can affect the success rate, which include inadequate primary implant stability when compared with delayed implants, inadequate soft tissue closure especially in case of thin tissue biotype, inability to inspect all aspects of the extraction site for defects or infection, and finally the added cost of bone grafting when the jumping distance is over 2mm.
Hyaluronic acid (HA) is one of the extracellular components of the connective tissue that belongs to the family of glycosaminoglycans, due to its non-immunogenic and non-toxic properties , it can be used in many medical fields such as dentistry, ophthalmology, dermatology.
HA has an important role in wound healing through inducing early granulation tissue formation, inhibiting destructive inflammatory process during the process of tissue healing, inducing re-epithelialization and angiogenesis.
HA not only acted as a carrier of growth factors and cells but also stimulated bone formation through chemotaxis, proliferation and differentiation of mesenchymal cells into osteoblasts. Although HA shares bone induction properties with osteogenic growth factors as bone morphogenic protein 2 and osteopontin.
HA also has anti-inflammatory effect through scavenging reactive oxygen species, such as superoxide radical (O2) and hydroxyl radical (OH) species, and inhibiting neutrophil derived serine proteinases, HA also has anti-edematous effect that may be related to its osmotic buffering capacity.
So surrounding of an implant with hyaluronic acid give a great potential to improve new bone formation and improve bone/implant contact which will improve healing time and implant stability.
This is the only study on the registry with Ibrahim Samy Kalboush as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
immediate dental implant with topical application of hyaluronic acid.
Device: immediate dental implant · Drug: Hyaluronic Acid
immediate dental implant placement with placebo gel
Device: immediate dental implant
immediate dental implant placement in freshly extracted socket.
Also known as: post extraction dental implant
topical application of hyaluronic acid
Also known as: gengigel
implant stability
implant stability using osstell "implant stability quotient (ISQ)"
Time frame: 6 months
soft tissue healing
assessment of soft tissue healing using likert scale from (0-4) with 0: Complete wound closure without presence of fibrin and 4:Incomplete wound closure (necrosis).
Time frame: 10 days
post operative pain
assessment of pain severity with 10 point visual analogue scale (VAS) no pain '0' to severe/unbearable pain '10'
Time frame: 0-2 and 7 days
Plan to share: No — i will check with my study chair
This study is completed, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.
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