An observational study in Intracytoplasmic Sperm Injection, sponsored by Assiut University. Status unknown. Open to female participants aged 18 Years to 38 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-09-24.
Sponsored by Assiut University · Observational
The aim of the current study is to investigate the pregnancy rate in women with normal uterine cavity and those detected or corrected uterine cavitary lesions, assessed by hysteroscopy in ICSI cycles.
Intrauterine pathology has been reported in up to 25% of infertile women having IVF treatment and in as many as 50% of women with recurrent implantation failure, leading to suggestions that correction of such pathology could improve treatment outcome. Hysteroscopy allows visual assessment of the cervical canal and uterine cavity and provides the opportunity to operate in the same setting. Routine outpatient hysteroscopy before starting IVF has been postulated to diagnose and treat abnormalities of the cervix and uterine cavity and hence improve IVF outcome.
A systematic review of published studies suggested that outpatient hysteroscopy in the menstrual cycle preceding an IVF treatment cycle could significantly increase the clinical pregnancy rate in women who had previously had recurrent implantation failure, even when no hysteroscopic abnormality was detected.
However, the result of the TROPHY study - published in the Lancet in 2016 concluded that Outpatient hysteroscopy before IVF in women with a normal ultrasound of the uterine cavity and a history of unsuccessful IVF treatment cycles does not improve the livebirth rate and they recommended that further research into the effectiveness of surgical correction of specific uterine cavity abnormalities before IVF is warranted.
An MD thesis done in our department on the evaluation of the endometrial cavity in infertile patients and prior to IVF recommended that there is an urgent need to RCT to emphasize the benefit of removal of the detected intrauterine lesions before proceeding to IVF.
Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
all infertile females will be assesed in IVF unite of women's health Hospital and will be recruted according to the inclusion criteria
Exclusion Criteria:
women with normal uterus,detected by hysteroscopy.
Procedure: hysteroscopy
Women with detected or corrected uterine cavitary lesions by hysteroscopy.
Procedure: hysteroscopy
office hysteroscopy will be done for all candidates and operative correction of detected lesions will be carried on.
Also known as: hysteroscopic uterine lesion detection or correction
Clinical pregnancy rate
Clinical pregnancy rate Will be evaluated
Time frame: 7th week of pregnancy for cardiac pulsations.
Chemical pregnancy rate Chemical pregnancy rate
Chemical pregnancy rate Chemical pregnancy rate
Time frame: 4 weeks
Implantation rate
Implantation rate for assessment of implanted embryos
Time frame: 6 weeks
Abortion rate
Abortion rate will be observed
Time frame: up to 28 week
Preterm labour rate
Delivary before term 37 weeks of pregnancy
Time frame: 9 months
No study locations are listed for this record.
Plan to share: Undecided
This study is status unknown, as verified in Sep 2018. You cannot join it, but the record below documents what was studied.
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Assiut University