An observational study in Decreased Lung Compliance and Oxygen Requirement, sponsored by AZ Sint-Jan AV. Completed at 1 site in Belgium. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-12-03.
Sponsored by AZ Sint-Jan AV · Observational
Opioids used intra operative increase the amount of opioids needed post operative to control post operative pain. if opioids are given post operative, we assume that more atelectasis and hypoxia takes place even after lung protective ventilation. These postoperative lower oxygen saturations will require giving more frequent oxygen therapy.
This is an observational study where the attending anesthesiologist decides to use opioid free or opioid general anesthesia based on his/her expertise.
Every patient gets a lung protective ventilation and emergence from anesthesia using the principles set forward in the consensus meeting by Young C BJA 2019.
A lung recruitment followed by high PEEP is given when lung compliance decreases below 40 ML/cmH20. The lowest oxygen saturation without adding oxygen therapy is noted post extubation at moment of admission in PACU, after having given an opioid as analgesic and at moment of discharge from PACU..
If post operative satuation drops below 94% oxygen therapy is given and noted.
AZ Sint-Jan AV is the lead sponsor of 58 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Major surgery requiring intubation and mechanical ventilation.
Exclusion Criteria:
classical anesthesia using sufentanil to block sympathetic reactions during surgery. This decision is based on the anesthesiologist experience and not determined by the patient or procedure.
Procedure: opioid anesthesia
anesthesia using non opioids like dexmedetomidine, lidocaine, magnesium and ketamine to block sympathetic reactions during surgery. This decision is based on the anesthesiologist experience and not determined by the patient or procedure.
Procedure: opioid free anesthesia
opioid anesthesia means using sufentanil during surgery
opioid free anesthesia means giving no opioids during surgery
oxygen requirement post operative to maintain saturation above 94%
oxygen saturation
Time frame: first 24 hours post operative
postoperative pain
postoperative pain measured by VAS score
Time frame: first 24 hours post operative
postoperative opioid consumption
postoperative opioid consumption measured by morphine equivalents
Time frame: first 24 hours post operative
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Dec 2019. You cannot join it, but the record below documents what was studied.
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AZ Sint-Jan AV