An interventional study of Desflurane Group and Propofol Group in Vision; Disorder, Loss, sponsored by University Hospital Hradec Kralove. Not yet recruiting at 1 site in Czechia. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2024-05-10.
Sponsored by University Hospital Hradec Kralove · Not applicable, Interventional, and Treatment
This study investigated the effect of desflurane and propofol anesthesia on visual acuity in patients in prone position for spinal surgery. Many trials have investigated the effects of different anesthetic agents on intraocular pressure, propofol may reduce intraocular pressure more than other intravenous anesthetics.
Perioperative increase in intraocular pressure can be caused by prone positioning. In addition to surgical factors, patients with glaucoma, uncontrolled hypertension, arthrosclerosis, and morbid obesity are at risk for potentially damaging optic nerve and loss of optic nerve function. Some studies found that intraocular pressure values were significantly lower in patients undergoing propofol total intravenous anesthesia than in patients undergoing desflurane anesthesia during intraoperative positional changes. Pronounced vasodilatation caused by desflurane might produced hyperaemia with higher intraocular pressure. Hemodynamic response to prone position measured by near-infrared spectroscopy (NIRS) on the prefrontal cortex could determine changes caused by prone position.
University Hospital Hradec Kralove is the lead sponsor of 46 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Induction and anesthesia will be held by using desflurane
Procedure: Desflurane Group
Induction and anesthesia will be held by using target-control anesthesia with propofol
Procedure: Propofol Group
General anesthesia will be held using desflurane in end- tidal concentration according to target value of entropy levels (between 40 and 60).
General anesthesia will be held using Schnider effect model for propofol (target control anesthesia). Titration will be done according to target value of entropy levels (between 40 and 60).
Visual injury
worsening of test for visual acuity (Rodenstock)
Time frame: 48 hours
This study is not yet recruiting, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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University Hospital Hradec Kralove