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CompletedNCT03636360Updated Mar 30, 2021

The Impact of Artificial Sunlight on Human Sleep and Circadian Rhythms

An interventional study of Light in Sleep, Circadian Dysregulation and Mood, sponsored by VA Palo Alto Health Care System. Completed at 1 site in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-03-30.

Sponsored by VA Palo Alto Health Care System · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
All
01

Study summary

The purpose of this study is to examine, in healthy controls, whether LED lighting that has a color spectrum similar to that of sunlight is able to differentially impact mood, circadian rhythms, sleep, and behavior, as compared to standard fluorescent lighting.

02

Conditions studied

  • Sleep
  • Circadian Dysregulation
  • Mood
03

In context

Chronobiology Disorders

89 studies on the registry are indexed under Chronobiology Disorders; 21 are open to participants now.

This study's enrollment of 10 is below the median of 65 across 58 interventional studies indexed under Chronobiology Disorders.

Browse Chronobiology Disorders studies →

Lead sponsor

VA Palo Alto Health Care System is the lead sponsor of 42 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Good self-reported health
  • Normal color vision

Exclusion criteria

Exclusion Criteria:

  • No sleep disorders
  • No extreme chronotype
  • Regular smoker
  • Significant hearing loss
  • Depression
  • Alcohol use disorder
  • Use of illegal drugs
  • Pregnant
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
10 participants (actual)

Study arms

  • Experimental
    LED - Sunlike

    LED lighting with spectral pattern similar to that of sunlight

    Device: Light

  • Active comparator
    Fluorescent

    Fluorescent light at same illuminance (lux) as LED light

    Device: Light

  • Placebo comparator
    Dim

    Dim fluorescent light with same spectrum as "Fluorescent" condition

    Device: Light

  • Active comparator
    LED

    Standard LED lighting

    Device: Light

Interventions

  • DeviceLight

    15 hours of light exposure

06

What researchers measure

Primary outcomes

  1. Alertness

    Change in median reaction time score on the auditory psychomotor vigilance test

    Time frame: 15 hours

  2. Melatonin suppression

    Amount of reduction in the concentration of salivary melatonin concentrations during an experimental light stimulus

    Time frame: 3 hours

Secondary outcomes

  1. Mood

    Change in total positive and negative affect scores on the Positive and Negative Affect Schedule (PANAS)

    Time frame: 15 hours

07

Study locations

1 site
  • VA Palo Alto Health Care System
    Palo Alto, California 94304, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 30, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03636360
Lead sponsor
VA Palo Alto Health Care System
Collaborators
Seoul Semiconductor
Responsible party
Jamie M. Zeitzer, Ph.D. (Associate Professor, VA Palo Alto Health Care System) — Principal investigator
First posted
Aug 17, 2018
Start date
Jul 1, 2019
Primary completion
Mar 1, 2021
Completion
Mar 1, 2021
Last update
Mar 30, 2021

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.

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