An interventional study of Product 1 and Product 2 in Healthy, sponsored by Société des Produits Nestlé (SPN). Completed at 1 site in Switzerland. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-03.
Sponsored by Société des Produits Nestlé (SPN) · Not applicable, Interventional, and Other
Sugar-sweetened beverages are the main source of added sugars in most Westernized countries, and for this reason constitute a primary target for sugar reduction by many companies, including Nestlé. Instead of using high-intensity sweeteners which are non-caloric in nature, an alternative would be to reduce sugars without altering sweetness.
In this protocol, the general goal is to investigate the relative contribution of sweet taste perception and sugar intake on post-prandial glucose response. 4 different nutritional products will be tested by 16 healthy subjects in a crossover design.
After enrollment, participants will be asked to come to the investigational site 6 times for:
Société des Produits Nestlé (SPN) is the lead sponsor of 314 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Normal glucose, isosweet, homogeneous: 43 g glucose beverage, with a 43 g glucose equivalent sweetness homogenously delivered
Other: Product 2 · Other: Product 3 · Other: Product 4
Low glucose, isosweet, heterogeneous: 30 g glucose beverage with 43 g glucose equivalent sweetness heterogeneously delivered
Other: Product 1 · Other: Product 3 · Other: Product 4
Low glucose, less sweet, homogeneous: 30 g glucose beverage with a 30 g glucose equivalent sweetness homogenously delivered
Other: Product 1 · Other: Product 2 · Other: Product 4
Low glucose+sucralose, isosweet, homogeneous: 30 g glucose + 18 mg sucralose beverage with a 43 g glucose equivalent sweetness homogenously delivered
Other: Product 1 · Other: Product 2 · Other: Product 3
Comparison with products 2, 3, and 4
Comparison with products 1, 3, and 4
Comparison with products 1, 2, and 4
Comparison with products 1, 2, and 3
Incremental Area under the Curve (iAUC) of plasma glucose
Area under the curve
Time frame: 0 to 3 hours post product intake
Incremental Area under the Curve (iAUC) of plasma insulin
Area under the curve
Time frame: 0 to 3 hours post product intake
Cmax of plasma glucose
Maximal concentration of plasma glucose
Time frame: between 0 and 3 hours post product intake
Cmax of plasma insulin
Maximal concentration of plasma insulin
Time frame: between 0 and 3 hours post product intake
Tmax of plasma glucose
Time (min) for maximal concentration of plasma glucose
Time frame: between 0 and 3 hours post product intake
Tmax of plasma insulin
Time (min) for maximal concentration of plasma insulin
Time frame: between 0 and 3 hours post product intake
Sensory tasting capacity
Assessment of the sweetness of two beverages versus control through a questionnaire
Time frame: immediately after product intake
This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.
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Société des Produits Nestlé (SPN)