An interventional study of Broncho Alveolar Lavages (BAL) in Smokers, Human Bronchial Epithelial Cells and Lung Pathogenesis, sponsored by Lille Catholic University. Completed. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-11.
Sponsored by Lille Catholic University · Not applicable, Interventional, and Basic science
Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease(COPD),asthma and lung cancer.
Evaluation and understanding of tobacco health effects are of major interest worldwide and answer to important societal concerns.
Identification of new biomarkers of exposure to tobacco smoke potentially implicated in COPD or lung carcinogenesis would allow a better observation of tobacco exposed population, thanks to screening establishment at reversible stages of pathological processes.
In this study, the main goal is to study whether cigarettes smoking alters miRNA profiles of extracellular vesicles (EVs) present in human broncho alveolar lavages (BALs), which could affect surrounding normal bronchial epithelial cells status.
Extracellular vesicles (EVs) include a variety of nanoscale membranous vesicles (exosomes, microvesicles, microparticles). EVs are released into the interstitial fluid from a wide variety of normal or diseased cells.
Analysis of EVs and their content maybe useful as disease biomarkers as they reflect the contents of cells of origin, differ between normal and diseased tissue and can be reliably detected.
EVs may thus act as biomarkers of diverse pathologies like cancer, and detection of these biomarkers maybe applied to early diagnosis or assessment of prognosis in patients with cancer. EVs indeed contain both mRNAs and non-coding RNAs, such as small regulatory microRNAs (miRNAs).
Lille Catholic University is the lead sponsor of 111 studies on the registry; 26 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Smokers outpatients at the Pneumology service from the HôpitalSaint-Philibert (Lomme, France) to whom a bronchoalveolar lavage will be performed
Diagnostic Test: Broncho Alveolar Lavages (BAL)
Non smokers outpatients at the Pneumology service from the HôpitalSaint-Philibert (Lomme, France) to whom a bronchoalveolar lavage will be performed
Diagnostic Test: Broncho Alveolar Lavages (BAL)
BEAS-2 B cells are exposed to EVs isolated from BAL of smokers and non-smokers.
Quantification of target mRNA expression in human bronchial epithelial cells (BEAS-2 B) exposed to EVs isolated from LBA of patients
Quantitative polymerase chain reaction (RT-qPCR) for determination of mRNA expression
Time frame: Through the study completion, an average of 48 months
No study locations are listed for this record.
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Lille Catholic University