An observational study in Recurrent Laryngeal Cancer, sponsored by First Affiliated Hospital, Sun Yat-Sen University. Status unknown at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2018-07-23.
Sponsored by First Affiliated Hospital, Sun Yat-Sen University · Observational
Advanced laryngeal squamous cell carcinoma (SCC) remains a highly morbid and fatal disease despite aggressive interventions. Mortality is high in this cohort: laryngeal cancer affects over 13 000 patients in the United States, with over 3500 deaths annually.The results of the Veterans Affairs Cooperative Studies Program Laryngeal Cancer Trial and subsequent studies demonstrated similar overall survival (OS) rates for organ preservation protocols involving radiotherapy (RT) or chemoradiotherapy (CRT) when compared to surgery, with the benefit of preserving the larynx in a large majority of patients. As such, the use of RT or CRT has become the predominant initial intervention for patients with laryngeal SCC.6 However, the prognosis of recurrent and persistent laryngeal SCC is particularly dire.In this study, we sought to identify preoperative predictors of survival for patients with recurrent or persistent laryngeal SCC in order to set patient expectations and address modifiable risk factors. Identification of predictors of survival may also identify patients who could benefit from novel therapeutic agents in a neo/adjuvant fashion. Herein,we examine a cohort of patients with recurrent or persistent laryngeal SCC after definitive RT/CRT who has undergone total laryngectomy in order to identify potential preoperative predictors of clinical outcomes.
Demographic, clinical, and survival data were abstracted. Death was verified via medical records and the social security death index. Primary outcome measures were OS (time from salvage laryngectomy to death from any cause), disease-specific survival (DSS; time from salvage laryngectomy to death from recurrent/persistent laryngeal SCC), and DFS (time from salvage laryngectomy to laryngeal SCC recurrence)
244 studies on the registry are indexed under Laryngeal Neoplasms; 63 are open to participants now.
This study's planned enrollment of 300 is above the median of 100 across 54 observational studies indexed under Laryngeal Neoplasms.
Browse Laryngeal Neoplasms studies →First Affiliated Hospital, Sun Yat-Sen University is the lead sponsor of 155 studies on the registry; 51 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients with laryngeal cancer
patients with a diagnosis of laryngeal squamous cell carcinoma
Exclusion Criteria:
multiple primarry malignant neo-plasms
Other: Recurrence laryngeal cancer
Other: Recurrence laryngeal cancer
Recurrence laryngeal cancer has a wide range of invasion, rapid progression and poor prognosis.
Overall survival
time from salvage laryngectomy to death from any cause
Time frame: Follow up 5 years
Plan to share: Undecided
No publications or documents are linked to this record.
This study is status unknown, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.
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First Affiliated Hospital, Sun Yat-Sen University