A Phase 3 interventional study of Sevoflurane and Isoflurane in Anesthesia, sponsored by Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine. Completed at 1 site in China. Open to participants aged 19 Years to 65 Years. Per ClinicalTrials.gov, last updated 2024-04-09.
Sponsored by Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine · Phase 3, Interventional, and Treatment
The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and isoflurane at equi-minimum alveolar concentration using EEG analysis.
Anesthetic agents vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there is no study that demonstrate the difference between analgesic potency of volatile anesthetics. The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and isoflurane at equi-minimum alveolar concentration using EEG analysis.
Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine is the lead sponsor of 6 studies on the registry; 1 is open to participants now.
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Anesthesia was maintained with sevoflurane.
Drug: Sevoflurane
Anesthesia was maintained with isoflurane.
Drug: Isoflurane
Anesthesia was maintained with sevoflurane in patients undergoing standardized nociceptive stimulus (long-lasting tetanic stimulus of the ulnar nerve; 30 s, 50 mA, 50 Hz, square-wave).
Also known as: SEVO
Anesthesia was maintained with isoflurane in patients undergoing standardized nociceptive stimulus (long-lasting tetanic stimulus of the ulnar nerve; 30 s, 50 mA, 50 Hz, square-wave).
Also known as: ISO
qCON index
The hypnotic potency of volatile anesthetics was evaluated by qCON index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).
Time frame: the 10 min at steady-state anesthesia after endotracheal intubation
qNOX index
The analgesic potency of volatile anesthetics was evaluated by qNOX index during standardized nociceptive stimulus (30 s, 50 mA, 50 Hz tetanic stimulation).
Time frame: the 10 min at steady-state anesthesia after endotracheal intubation
This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.
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Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine