An observational study in Compare Serum Level of Klotho in Patients on Oral Antidiabetic Treatment, sponsored by Fayoum University. Status unknown at 1 site in Egypt. Open to participants aged 30 Years and older. Per ClinicalTrials.gov, last updated 2018-07-13.
Sponsored by Fayoum University · Observational
Klotho is a protein found in serum, kidney,heart,brain and in other tissues,it has many functions,it is viewed as the anti aging hormone. Aging kidneys are characterized by progressive scarring and measurable declines in renal function
Objectives To study serum klotho level among diabetic patients attending diabetes and endocrine clinic in Fayoum university on oral antidiabetic treatment
Study Design:
This study will be an observational prospective cohort study. The study duration will be 2 months.
Study Methods:
Diabetics candidate for insulin treatment
There will be three arms to this study; the first arm will enroll patients on glimepiride and patients on metformin to compare serum klotho levels. The second arm will enroll patients on glimepiride and patients on linagliptin to compare serum klotho levels. The third arm will enroll patients on glimepiride and patients on impaglifluzin to compare serum klotho levels Each arm will enroll 40 patients, 20 patients on glimiperide treatment,20 patient will on the other drug,patients will be selected from Fayoum university diabetes and endocrine clinic
Data collection:
Patients will be subjected to; full clinical examination,waist hip ratio assessment,BMI assessment fasting blood glucose,2PP blood glucose,HbA1C, urea, creatinine, uric acid total calcium,albumin, phospherus, estimated GFR, ACR, total cholesterol, triglycerides, serum klotho, FGF 23 levels assessment , also fracrtional excretion of phospherus will be assessed. Control of blood glucose will be done along the period of the study. At the end of the 2 months,reassessment of the above mentioned parameters will be done.
Fayoum University is the lead sponsor of 144 studies on the registry; 41 are open to participants now.
Counted across the registry records on this site, refreshed daily.
type 2 diabetics on oral treatment
Exclusion Criteria:
Compare serum levels of klotho in patients taking glimepiride in comparison to patients taking metformin
Compare serum levels of klotho in patients taking glimepiride in comparison to patients taking linagliptin
Compare serum levels of klotho in patients taking glimepiride in comparison to patients taking impaglifluzin
Beneficial effect manifested by a statistical significant decrease in klotho levels
An anticipated statistical significant decrease in klotho level
Time frame: 2 months
No beneficial effect manifested by by a non significant decrease in klotho level or a rise in the level
Non statistical significant decrease in klotho level, or a significant rise in it
Time frame: 2 months
Plan to share: Undecided
No publications or documents are linked to this record.
This study is status unknown, as verified in Jun 2018. You cannot join it, but the record below documents what was studied.
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Fayoum University