An interventional study of Lidocaine and Histamine in Itch, Thermal Stimulation and Histamine, sponsored by Aalborg University. Completed at 1 site in Denmark. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-07-08.
Sponsored by Aalborg University · Not applicable, Interventional, and Basic science
The purpose of this human experimental study is to evaluate the pattern of itch intensity over time in response to strong, short-term heat stimulation in two different models of histamine and cowhage-induced itch. Moreover, the purpose is to evaluate the effect of mild pre-heating of the skin in human experimental models of histamine, cowhage and serotonin. Finally, we want to investigate the effect of short-term intense heat stimulation on previously anesthetized skin.
Aalborg University is the lead sponsor of 178 studies on the registry; 37 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Other: Histamine · Other: Cowhage · Other: Heat stimulation
Other: Histamine · Other: Cowhage · Other: Pre-heating · Other: Serotonin
Drug: Lidocaine · Other: Heat stimulation
Lidocaine intradermal injection
Skin Prick Test with Histamine
Manually skin insertion of cowhage spicules
Short heat stimulation
Mild skin pre-heating
Serotonin electrophoresis
eVAS Itch
Electronic Visual Analog Scale for itch sensation. 0-100 scale, it measures the self-estimated itch the subject experience on a scale where 0 correspond to "No itch" and 100 "Worst itch imaginable".
Time frame: 10 minutes
Skin temperature
Infrared skin thermometer
Time frame: 5 seconds
eVAS Pain
Electronic Visual Analog Scale for pain sensation. 0-100 scale, it measures the self-estimated pain the subject experience on a scale where 0 correspond to "No pain" and 100 "Worst pain imaginable".
Time frame: 10 minutes
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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Aalborg University